|PROSITE documentation PDOC00411 [for PROSITE entry PS00446]|
In eukaryotes, there are three different forms of DNA-dependent RNA polymerases (EC 22.214.171.124) transcribing different sets of genes. Each class of RNA polymerase is an assemblage of ten to twelve different polypeptides. In archaebacteria, there is generally a single form of RNA polymerase which also consist of an oligomeric assemblage of 10 to 13 polypeptides.
As a signature pattern for these subunits, we selected a conserved region in their N-terminal part.Last update:
December 2004 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Kolodziej P., Young R.A.|
|Title||RNA polymerase II subunit RPB3 is an essential component of the mRNA transcription apparatus.|
|Source||Mol. Cell. Biol. 9:5387-5394(1989).|
|2||Authors||Pati U.K., Weissman S.M.|
|Title||The amino acid sequence of the human RNA polymerase II 33-kDa subunit hRPB 33 is highly conserved among eukaryotes.|
|Source||J. Biol. Chem. 265:8400-8403(1990).|
|3||Authors||Azuma Y., Yamagishi M., Ishihama A.|
|Title||Subunits of the Schizosaccharomyces pombe RNA polymerase II: enzyme purification and structure of the subunit 3 gene.|
|Source||Nucleic Acids Res. 21:3749-3754(1993).|