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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00488


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PURL: https://purl.expasy.org/prosite/signature/PS00488

Direct ScanProsite submission
General information about the entry

Entry name [info] PAL_HISTIDASE
Accession [info] PS00488
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00424
Associated ProRule [info] PRU10122

Name and characterization of the entry

Description [info] Phenylalanine and histidine ammonia-lyases signature.
Pattern [info] 
[GS]-[STG]-[LIVM]-[STG]-[SAC]-S-G-[DH]-L-x-[PN]-L-[SA]-x(2,3)-[SAGVTL].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 274 in 274 different sequences
Number of true positive hits 274 in 274 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 1
Number of 'partial' sequences 4
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 99.64 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 6
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 274 sequences 

CCTP1_TALIS (P9WEN6), CLZ10_COCLU (A0A345BJN1), HALL_DICDI  (Q556V9), 

HKM12_ASPHA (P0DUM0), HUTH1_CAEEL (Q20502), HUTH1_FUSNN (Q8RFC2), 
HUTH2_FUSNN (Q8RDU4), HUTH_ACICJ  (A5FZB9), HUTH_AGRFC  (Q8U8Z7), 
HUTH_ALIF1  (Q5E0C6), HUTH_ALIFM  (B5ETN1), HUTH_ALKMQ  (A6TSX0), 
HUTH_ALKOO  (A8MF64), HUTH_ALLAM  (B9K288), HUTH_ANAD2  (B8J950), 
HUTH_ANADE  (Q2IIV4), HUTH_ANASK  (B4UC43), HUTH_AROAE  (Q5NZX8), 
HUTH_BACAA  (C3P4M2), HUTH_BACAC  (C3L982), HUTH_BACAH  (A0RH39), 
HUTH_BACAN  (Q81Y45), HUTH_BACC0  (B7JI80), HUTH_BACC1  (Q733H8), 
HUTH_BACC2  (B7ISJ2), HUTH_BACC3  (C1EN93), HUTH_BACC4  (B7HCD0), 
HUTH_BACC7  (B7HKJ1), HUTH_BACCN  (A7GR00), HUTH_BACCQ  (B9IUH0), 
HUTH_BACCR  (Q81AC6), HUTH_BACCZ  (Q637H8), HUTH_BACHK  (Q6HFE9), 
HUTH_BACMK  (A9VPT8), HUTH_BACSU  (P10944), HUTH_BACVZ  (A7ZAE4), 
HUTH_BARHE  (Q6G3U8), HUTH_BARQU  (Q6FZP9), HUTH_BART1  (A9IVW5), 
HUTH_BOVIN  (A7YWP4), HUTH_BRADU  (Q89GV3), HUTH_BRASB  (A5EQB7), 
HUTH_BRASO  (A4YNK7), HUTH_BRUA1  (B2SD96), HUTH_BRUA2  (Q2YIL6), 
HUTH_BRUA4  (A6WYU8), HUTH_BRUAB  (Q579E8), HUTH_BRUC2  (A9MCL0), 
HUTH_BRUO2  (A5VVJ6), HUTH_BRUSI  (A9WVU3), HUTH_BRUSU  (Q8FVB4), 
HUTH_BURA4  (B1YT80), HUTH_BURCH  (A0K8U6), HUTH_BURCJ  (B4EDX5), 
HUTH_BURCM  (Q0BDK6), HUTH_BURL3  (Q39EP0), HUTH_BURM1  (A9AGP7), 
HUTH_BURM7  (A3MLT7), HUTH_BURM9  (A2SA96), HUTH_BURMA  (Q62LJ6), 
HUTH_BURO0  (B1JV50), HUTH_BURO1  (Q1BHY5), HUTH_BURP0  (A3NXA3), 
HUTH_BURP6  (A3NBH0), HUTH_BURPS  (Q63SH6), HUTH_BURVG  (A4JG46), 
HUTH_CALS4  (Q8RBH4), HUTH_CAUSK  (B0SYU6), HUTH_CAUVC  (P58082), 
HUTH_CAUVN  (B8H2S1), HUTH_CERS1  (A3PK23), HUTH_CERS4  (Q3J289), 
HUTH_CERSK  (B9KSW6), HUTH_CHESB  (Q11E18), HUTH_CHLAA  (A9WHT8), 
HUTH_CHLSY  (B9LLY0), HUTH_CHRVO  (Q7P188), HUTH_CITK8  (A8AJ15), 
HUTH_CLOTE  (Q891Q1), HUTH_DEIDV  (C1CWB4), HUTH_DEIRA  (Q9RZ06), 
HUTH_DESPS  (Q6AKP3), HUTH_DICDI  (Q54JI7), HUTH_ENT38  (A4W8B5), 
HUTH_GEOKA  (Q5L310), HUTH_GEOSW  (C5D4K1), HUTH_GEOTN  (A4IK90), 
HUTH_GLOVI  (Q7NCB3), HUTH_GLUDA  (A9H863), HUTH_GLUOX  (Q5FRR8), 
HUTH_HALH5  (Q9KBE6), HUTH_HALS3  (B0R544), HUTH_HALSA  (Q9HQD5), 
HUTH_HUMAN  (P42357), HUTH_HYPNA  (Q0BZK2), HUTH_IDILO  (Q5QV30), 
HUTH_KLEP3  (B5XZ79), HUTH_KLEP7  (A6T6L1), HUTH_KORVE  (Q1IRT8), 
HUTH_LEGPA  (Q5X5I5), HUTH_LEGPC  (A5IBM2), HUTH_LEGPH  (Q5ZVR0), 
HUTH_LEGPL  (Q5WWW8), HUTH_MACCJ  (B9E7E0), HUTH_MARMM  (Q0AP92), 
HUTH_METNO  (B8II08), HUTH_METS4  (B0UQ15), HUTH_MOUSE  (P35492), 
HUTH_MYXXD  (Q1D6R1), HUTH_NATTJ  (B2A3D9), HUTH_PARC0  (A1TRE4), 
HUTH_PARDP  (A1AZX9), HUTH_PARPJ  (B2T2Y2), HUTH_PHEZH  (B4RED8), 
HUTH_PHOLL  (Q7N296), HUTH_PHOPR  (Q6LQ56), HUTH_PSEA6  (Q15X40), 
HUTH_PSEA8  (B7V3J1), HUTH_PSEAB  (Q02ER8), HUTH_PSEAE  (Q9HU85), 
HUTH_PSEFS  (Q8VMR3), HUTH_PSEPF  (Q3KJE6), HUTH_PSEPK  (Q88CZ7), 
HUTH_PSEPU  (P21310), HUTH_PSESM  (Q87UM1), HUTH_PSYCK  (Q1Q9E4), 
HUTH_PSYIN  (A1STQ3), HUTH_PSYWF  (A5WDR1), HUTH_RALN1  (Q8XW29), 
HUTH_RAT(P21213), HUTH_RHILO  (Q983I0), HUTH_RHIME  (O31197), 
HUTH_RHIR8  (B9JDC0), HUTH_RHIRH  (Q9KWE4), HUTH_RHOCS  (B6IWC6), 
HUTH_ROSDO  (Q162E2), HUTH_RUEPO  (Q5LRD8), HUTH_SALA4  (B5F069), 
HUTH_SALAR  (A9MJE9), HUTH_SALCH  (Q57RG6), HUTH_SALDC  (B5FP58), 
HUTH_SALEP  (B5QX62), HUTH_SALG2  (B5R758), HUTH_SALHS  (B4TC45), 
HUTH_SALNS  (B4SZJ4), HUTH_SALPA  (Q5PG61), HUTH_SALPB  (A9MTJ1), 
HUTH_SALPC  (C0PWX9), HUTH_SALPK  (B5BC34), HUTH_SALSV  (B4TQT6), 
HUTH_SALTI  (Q8Z896), HUTH_SALTY  (Q8ZQQ9), HUTH_SHEON  (Q8EKJ4), 
HUTH_SHEPA  (A8HA91), HUTH_SHEPW  (B8CGY5), HUTH_SHESH  (A8G1S5), 
HUTH_SHEWM  (B1KP55), HUTH_SHOC1  (Q5WAZ6), HUTH_SORC5  (A9GFW6), 
HUTH_SPHAL  (Q1GSH0), HUTH_STAA2  (A6TXF8), HUTH_STAA3  (Q2FKP8), 
HUTH_STAA8  (Q2G2P7), HUTH_STAA9  (A5INP9), HUTH_STAAB  (Q2YUR3), 
HUTH_STAAC  (Q5HJY8), HUTH_STAAE  (A6QD47), HUTH_STAAM  (P64415), 
HUTH_STAAN  (P64416), HUTH_STAAR  (Q6GKT7), HUTH_STAAS  (Q6GD82), 
HUTH_STAAT  (A8YYT1), HUTH_STAAW  (Q8NYY3), HUTH_STAS1  (Q4A173), 
HUTH_STIAU  (Q93TX3), HUTH_STRAW  (Q82I33), HUTH_STRCO  (Q9EWW1), 
HUTH_STRGC  (A8AZ70), HUTH_STRGR  (P24221), HUTH_STRP1  (P58083), 
HUTH_STRP3  (P0DB74), HUTH_STRP6  (Q5X9K4), HUTH_STRP8  (Q8NZ46), 
HUTH_STRPG  (A2RGS5), HUTH_STRPQ  (P0DB75), HUTH_STRPZ  (B5XIY2), 
HUTH_STRSV  (A3CL24), HUTH_SYMTH  (Q67JH4), HUTH_THEAC  (Q9HLI6), 
HUTH_THEVO  (Q978N8), HUTH_TREDE  (Q73Q56), HUTH_VIBCH  (Q9KSQ4), 
HUTH_VIBPA  (Q87Q77), HUTH_VIBVU  (Q8DA21), HUTH_VIBVY  (Q7MK58), 
HUTH_XANAC  (Q8PLZ8), HUTH_XANC8  (Q4UTB9), HUTH_XANCB  (B0RUX3), 
HUTH_XANCP  (Q8PAA7), HUTH_YERE8  (A1JSW6), HUTH_YERPE  (Q8ZA10), 
HUTH_YERPS  (Q664B8), HUTIH_BRUME (Q8YD09), LENB_ASPLE  (A0AAN4PAE6), 
MFM7_PHOSM  (A0A3G1DJK5), PAL1_ARATH  (P35510), PAL1_DAUCA  (O23865), 
PAL1_FRIUN  (P0DO55), PAL1_IPOBA  (P14166), PAL1_LITER  (O49835), 
PAL1_NARPS  (A0A2H5AIW0), PAL1_ORYSJ  (P14717), PAL1_PEA(Q01861), 
PAL1_PETCR  (P24481), PAL1_PETHY  (Q50EX7), PAL1_POPKI  (P45731), 
PAL1_PRUAV  (O64963), PAL1_RUBID  (Q9M568), PAL1_SOLLC  (P35511), 
PAL1_SOLTU  (P31425), PAL1_SOYBN  (P27991), PAL1_TOBAC  (P25872), 
PAL2_ARATH  (P45724), PAL2_CICAR  (Q9SMK9), PAL2_IPOBA  (Q42858), 
PAL2_LITER  (O49836), PAL2_NARPS  (A0A2H5AIY6), PAL2_ORYSI  (A2X7F7), 
PAL2_ORYSJ  (Q0DZE0), PAL2_PEA(Q04593), PAL2_PETCR  (P45728), 
PAL2_PHAVU  (P19142), PAL2_POPKI  (Q43052), PAL2_SOLTU  (P31426), 
PAL2_TOBAC  (P35513), PAL3_ARATH  (P45725), PAL3_PETCR  (P45729), 
PAL3_PHAVU  (P19143), PAL3_TOBAC  (P45733), PAL4_ARATH  (Q9SS45), 
PAL4_POPKI  (Q40910), PAL5_SOLLC  (P26600), PALY1_PLEOS (A0A4Y6HUI7), 
PALY2_PLEOS (A0A4Y6HUD7), PALY_AMAMU  (O93967), PALY_BROFI  (Q42609), 
PALY_CAMSI  (P45726), PALY_CITLI  (Q42667), PALY_DIGLA  (O23924), 
PALY_FLAVE  (A0A0A7AAW9), PALY_HELAN  (O04058), PALY_MAIZE  (Q8VXG7), 
PALY_MEDSA  (P27990), PALY_MYCMD  (Q96V77), PALY_PERAE  (P45727), 
PALY_PINTA  (P52777), PALY_POPTR  (P45730), PALY_RHOMI  (P10248), 
PALY_RHOTO  (P11544), PALY_STYHU  (P45732), PALY_TRIMT  (X2BTY5), 
PALY_TRISU  (P45734), PALY_WHEAT  (Q43210), PAL_NOSP7   (B2J528), 
PAL_TRIV2   (Q3M5Z3), PAM_TAXCA   (Q6GZ04), PAM_TAXCH   (Q68G84), 
STR11_STRTC (A0A384XHA3), TALY_CERS4  (Q3IWB0), TALY_CUPMC  (Q1LRV9), 
TAM_CHOCO   (Q0VZ68), TAM_MYXFU   (B8ZV93), TAM_MYXSM   (B8ZV94), 
TAM_STRGL   (Q8GMG0)
» more

UniProtKB/Swiss-Prot
False negative sequences		 1 sequence 

HUTH_RHORT  (Q2RUU3)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			4 sequences
			


			
PAL1_PHAVU  (P07218), PALY_AGABI  (Q92195), PALY_MALDO  (P35512), 

			
PALY_VITVI  (P45735)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			41 PDB
			


			pdb_00001b8f; pdb_00001eb4; pdb_00001gk2; pdb_00001gkj; pdb_00001gkm; pdb_00001t6j; pdb_00001t6p; pdb_00001w27; pdb_00001y2m; pdb_00002nyf; pdb_00002nyn; pdb_00002o6y; 
			
				pdb_00002o78; pdb_00002o7b; pdb_00002o7d; pdb_00002o7e; pdb_00002o7f; pdb_00002ohy; pdb_00002qve; pdb_00002rjr; pdb_00002rjs; pdb_00002yii; pdb_00003czo; pdb_00003kdy; 
				pdb_00003kdz; pdb_00003nz4; pdb_00004baa; pdb_00004bab; pdb_00004c5r; pdb_00004c5s; pdb_00004c5u; pdb_00004c6g; pdb_00004cq5; pdb_00004v2q; pdb_00004v2r; pdb_00005ltm; 
				pdb_00006f6t; pdb_00006h2o; pdb_00006hqf; pdb_00006rgs; pdb_00007tqr
			
			

			» more