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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00491


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PURL: https://purl.expasy.org/prosite/signature/PS00491

Direct ScanProsite submission
General information about the entry

Entry name [info] PROLINE_PEPTIDASE
Accession [info] PS00491
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00417

Name and characterization of the entry

Description [info] Aminopeptidase P and proline dipeptidase signature.
Pattern [info]
[HA]-[GSYR]-[LIVMT]-[SG]-H-x-[LIV]-G-[LIVMNKS]-x-[IVEL]-[HNC]-[DEV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 239 in 239 different sequences
Number of true positive hits 239 in 239 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 47
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 83.57 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
239 sequences

AMPEP_HELPY (O25681), AMPP1_AJECG (C0NDZ7), AMPP1_AJECH (C6HSY3), 
AMPP1_AJECN (A6R035), AMPP1_AJEDR (C5GXZ9), AMPP1_ARATH (F4JQH3), 
AMPP1_ARTGP (E4USI8), AMPP1_ARTOC (C5FHR9), AMPP1_ASPCL (A1CAQ1), 
AMPP1_ASPFC (B0Y3V7), AMPP1_ASPFN (B8NEI6), AMPP1_ASPFU (Q4WUD3), 
AMPP1_ASPNC (A2QGR5), AMPP1_ASPOR (Q2U7S5), AMPP1_ASPTN (Q0CDB3), 
AMPP1_BLAGS (C5K105), AMPP1_BOTFB (A6RK67), AMPP1_CHAGB (Q2H8T2), 
AMPP1_COCP7 (C5P7J2), AMPP1_COCPS (E9CTR7), AMPP1_COLGM (E3QCU0), 
AMPP1_EMENI (Q5AVF0), AMPP1_FUSV7 (C7Z9Z7), AMPP1_LEPMJ (E5ABQ8), 
AMPP1_LOTJA (A0A2Z5GDY5), AMPP1_METAQ (E9E9B2), AMPP1_METRA (E9EUE6), 
AMPP1_NEOFI (A1DF27), AMPP1_NEUCR (Q7RYL6), AMPP1_PARBA (C1H978), 
AMPP1_PARBD (C1GEY4), AMPP1_PARBP (C0SCV1), AMPP1_PENRW (B6HQC9), 
AMPP1_PHANO (Q0UFY4), AMPP1_PODAN (B2AWV6), AMPP1_PYRO7 (A4RF35), 
AMPP1_PYRTR (B2VUU7), AMPP1_PYRTT (E3S7K9), AMPP1_SCLS1 (A7E4T8), 
AMPP1_SORMK (D1ZKF3), AMPP1_STRCO (P0A3Z1), AMPP1_STRLI (P0A3Z2), 
AMPP1_TUBMM (D5GAC6), AMPP1_VERA1 (C9SR45), AMPP2_AJECG (C0NF18), 
AMPP2_AJECH (C6HNY5), AMPP2_AJECN (A6QYF6), AMPP2_AJEDR (C5GKT2), 
AMPP2_ARTBC (D4B0B2), AMPP2_ARTGP (E4V1Q7), AMPP2_ARTOC (C5FUV0), 
AMPP2_ASPCL (A1CNW6), AMPP2_ASPFC (B0XN37), AMPP2_ASPFN (B8MZI5), 
AMPP2_ASPFU (Q4WRV9), AMPP2_ASPNC (A2QAW7), AMPP2_ASPOR (Q2UQH9), 
AMPP2_ASPTN (Q0CZM6), AMPP2_BLAGS (C5K0R2), AMPP2_BOTFB (A6SL16), 
AMPP2_CHAGB (Q2HA12), AMPP2_COCP7 (C5PAH2), AMPP2_COCPS (E9CY14), 
AMPP2_COLGM (E3Q897), AMPP2_EMENI (Q5BF48), AMPP2_METAQ (E9E2J4), 
AMPP2_METRA (E9F9J8), AMPP2_NEOFI (A1D1S6), AMPP2_PARBA (C1H3X3), 
AMPP2_PARBD (C1GHS9), AMPP2_PARBP (C0SDW6), AMPP2_PENRW (B6HAN0), 
AMPP2_PHANO (Q0V147), AMPP2_PODAN (B2AW39), AMPP2_PYRTR (B2WKR4), 
AMPP2_PYRTT (E3RNJ5), AMPP2_SCLS1 (A7ENP9), AMPP2_STRCO (P0A3Z3), 
AMPP2_STRLI (P0A3Z4), AMPP2_TALMQ (B6QAW7), AMPP2_TALSN (B8M2W9), 
AMPP2_TRIVH (D4D6B8), AMPP2_UNCRE (C4JY72), AMPP3_SORMK (D1ZBF6), 
AMPP_ECOLI  (P15034), AMPP_HAEIN  (P44881), AMPP_MYCGE  (P47566), 
AMPP_MYCPN  (P75313), AMPP_PLAF7  (A0A144A2H0), FRA1_YEAST  (Q07825), 
ICP55_SCHPO (Q10439), ICP55_YEAST (P40051), PEPD_HUMAN  (P12955), 
PEPD_MOUSE  (Q11136), PEPD_PONAB  (Q5RFB3), PEPD_RAT(Q5I0D7), 
PEPE_MYCBO  (P65811), PEPE_MYCTO  (P9WHS6), PEPE_MYCTU  (P9WHS7), 
PEPQ1_IDILO (Q5QXH5), PEPQ2_IDILO (Q5QVP2), PEPQ_ACTP2  (A3MYG3), 
PEPQ_ACTP7  (B3GZT0), PEPQ_AERHH  (A0KEL3), PEPQ_AERS4  (A4STF0), 
PEPQ_ALTSX  (Q44238), PEPQ_CITK8  (A8ACZ6), PEPQ_COLP3  (Q48AT5), 
PEPQ_CROS8  (A7MQN9), PEPQ_ECO24  (A7ZU52), PEPQ_ECO27  (B7UNH5), 
PEPQ_ECO45  (B7MHD2), PEPQ_ECO55  (B7L9A5), PEPQ_ECO57  (Q8X8I1), 
PEPQ_ECO5E  (B5YY94), PEPQ_ECO7I  (B7NV19), PEPQ_ECO81  (B7N2F3), 
PEPQ_ECO8A  (B7M650), PEPQ_ECOBW  (C5A021), PEPQ_ECODH  (B1XAK9), 
PEPQ_ECOHS  (A8A6V2), PEPQ_ECOK1  (A1AI34), PEPQ_ECOL5  (Q0TAK9), 
PEPQ_ECOL6  (Q8FBI1), PEPQ_ECOLC  (B1IW60), PEPQ_ECOLI  (P21165), 
PEPQ_ECOLU  (B7NFE8), PEPQ_ECOSE  (B6I4I7), PEPQ_ECOSM  (B1LM33), 
PEPQ_ECOUT  (Q1R465), PEPQ_EDWI9  (C5BCB6), PEPQ_ENT38  (A4WFX3), 
PEPQ_ERWT9  (B2VFE3), PEPQ_ESCF3  (B7LTY8), PEPQ_GLAP5  (B8F8H3), 
PEPQ_HAHCH  (Q2S6U2), PEPQ_KLEP3  (B5XYG9), PEPQ_KLEP7  (A6TGM5), 
PEPQ_LACDE  (Q9S6S1), PEPQ_LACDL  (P46545), PEPQ_LACHE  (O84913), 
PEPQ_MARN8  (A1TXT7), PEPQ_PECAS  (Q6DAP4), PEPQ_PECCP  (C6DI64), 
PEPQ_PHOLL  (Q7MZ93), PEPQ_PROMH  (B4EWE3), PEPQ_PSEA6  (Q15ZF7), 
PEPQ_PSET1  (Q3IJ21), PEPQ_PYRFU  (P81535), PEPQ_PYRHO  (O58885), 
PEPQ_SALA4  (B5EZW1), PEPQ_SALAR  (A9MIX1), PEPQ_SALCH  (Q57HM5), 
PEPQ_SALDC  (B5FNX9), PEPQ_SALEP  (B5QW86), PEPQ_SALG2  (B5RFL5), 
PEPQ_SALHS  (B4TBS6), PEPQ_SALNS  (B4SZ86), PEPQ_SALPA  (Q5PKQ1), 
PEPQ_SALPB  (A9MYB1), PEPQ_SALPC  (C0Q3F4), PEPQ_SALPK  (B5BIZ1), 
PEPQ_SALSV  (B4TNZ2), PEPQ_SALTI  (Q9L6L4), PEPQ_SALTY  (Q7CPD4), 
PEPQ_SERP5  (A8G8D3), PEPQ_SHEAM  (A1S1I9), PEPQ_SHEB2  (B8E3R4), 
PEPQ_SHEB5  (A3CYJ5), PEPQ_SHEB8  (A6WHA1), PEPQ_SHEB9  (A9KU92), 
PEPQ_SHEDO  (Q12TB3), PEPQ_SHEFN  (Q08A38), PEPQ_SHEHH  (B0TLC0), 
PEPQ_SHELP  (A3Q8U5), PEPQ_SHEON  (Q8EKR8), PEPQ_SHEPA  (A8GYG1), 
PEPQ_SHEPC  (A4Y1B7), PEPQ_SHEPW  (B8CHA2), PEPQ_SHESA  (A0KR51), 
PEPQ_SHESH  (A8FP64), PEPQ_SHESM  (Q0HPB6), PEPQ_SHESR  (Q0I0T2), 
PEPQ_SHESW  (A1RDW7), PEPQ_SHEWM  (B1KCZ4), PEPQ_SHIB3  (B2TVJ6), 
PEPQ_SHIBS  (Q31UE2), PEPQ_SHIDS  (Q32A22), PEPQ_SHIF8  (Q0SZ37), 
PEPQ_SHIFL  (Q83PG0), PEPQ_SHISS  (Q3YVC0), PEPQ_SODGM  (Q2NWT2), 
PEPQ_STRM5  (B4SI11), PEPQ_STRMK  (B2FT23), PEPQ_XANAC  (Q8PH57), 
PEPQ_XANC8  (Q4UY33), PEPQ_XANCB  (B0RP90), PEPQ_XANCP  (Q8P5S9), 
PEPQ_XANE5  (Q3BPR2), PEPQ_XANOM  (Q2P6N8), PEPQ_XANOR  (Q5H3T0), 
PEPQ_YERE8  (A1JIG5), PEPQ_YERP3  (A7FDF3), PEPQ_YERPA  (Q1C2C5), 
PEPQ_YERPB  (B2K0Z7), PEPQ_YERPE  (Q0WAP4), PEPQ_YERPG  (A9R755), 
PEPQ_YERPN  (Q1CN98), PEPQ_YERPP  (A4TR26), PEPQ_YERPS  (Q66FR7), 
PEPQ_YERPY  (B1JP62), XPP1_BOVIN  (Q1JPJ2), XPP1_DICDI  (Q54G06), 
XPP1_HUMAN  (Q9NQW7), XPP1_MOUSE  (Q6P1B1), XPP1_RAT(O54975), 
XPP2_HUMAN  (O43895), XPP2_MOUSE  (B1AVD1), XPP2_PIG(Q95333), 
XPP2_RAT(Q99MA2), Y1059_STAS1 (Q49YD7), Y1217_STAHJ (Q4L749), 
Y1271_STAEQ (Q5HNJ7), Y1383_STAES (Q8CNW9), Y1530_STAAN (Q7A552), 
Y1567_STAAB (Q2YTD2), Y1635_STAAS (Q6G8L9), Y1651_STAAW (Q8NW55), 
Y1654_STAA3 (Q2FG30), Y1708_STAAM (Q99TF5), Y1756_STAAC (Q5HF67), 
Y1786_STAAR (Q6GFZ9), Y1816_STAA8 (Q2FXL9), Y806_METJA  (Q58216), 
YAA1_SCHPO  (Q09795), YFH6_YEAST  (P43590), YKVY_BACSU  (O31689), 
YOD1_SCHPO  (Q9UUD8), YQHT_BACSU  (P54518)
» more

UniProtKB/Swiss-Prot
False negative sequences
47 sequences

AMPP1_ARTBC (D4ARJ9), AMPP1_COPC7 (A8P5H7), AMPP1_LACBS (B0DZL3), 
AMPP1_TALMQ (B6QG01), AMPP1_TALSN (B8M9W2), AMPP1_TRIVH (D4D891), 
AMPP2_FUSV7 (C7Z837), AMPP2_NEUCR (A7UWH7), AMPP2_PYRO7 (A4RQ11), 
AMPP2_SORMK (D1ZQL9), AMPP2_TUBMM (D5GHP2), AMPP2_VERA1 (C9SDK8), 
AMPP3_AJECG (C0NIF0), AMPP3_AJECH (C6H7R7), AMPP3_AJEDR (C5G874), 
AMPP3_ASPCL (A1CSI0), AMPP3_ASPFC (B0XW47), AMPP3_ASPFN (B8NC10), 
AMPP3_ASPFU (Q4X267), AMPP3_ASPNC (A2QKF6), AMPP3_ASPTN (Q0CFZ0), 
AMPP3_BLAGS (C5JQ04), AMPP3_BOTFB (A6SDE9), AMPP3_COCP7 (C5PHM7), 
AMPP3_COCPS (E9DDK8), AMPP3_EMENI (Q96WX8), AMPP3_FUSV7 (C7YVN8), 
AMPP3_LEPMJ (E4ZHV7), AMPP3_METAQ (E9DV56), AMPP3_METRA (E9EK74), 
AMPP3_NEOFI (A1DG66), AMPP3_PARBA (C1H9Q9), AMPP3_PARBD (C1GD57), 
AMPP3_PARBP (C0SHQ0), AMPP3_PENRW (B6H2M0), AMPP3_PHANO (Q0U6G5), 
AMPP3_PODAN (B2AFW1), AMPP3_PYRO7 (A4RAE9), AMPP3_PYRTR (B2WMQ2), 
AMPP3_PYRTT (E3S6N7), AMPP3_SCLS1 (A7EUB3), AMPP3_TALMQ (B6Q8T5), 
AMPP3_TALSN (B8M0Z4), AMPP3_UNCRE (C4JF09), AMPP3_VERA1 (C9SEV5), 
PEPD_DICDI  (Q55E60), PEPQ_PSEHA  (P77814)
» more

PDB
[Detailed view]
58 PDB

pdb_00001a16; pdb_00001jaw; pdb_00001m35; pdb_00001n51; pdb_00001pv9; pdb_00001w2m; pdb_00001w7v; pdb_00001wbq; pdb_00001wl6; pdb_00001wl9; pdb_00001wlr; pdb_00001wy2; pdb_00002bh3; pdb_00002bha; pdb_00002bhb; pdb_00002bhc; pdb_00002bhd; pdb_00002bn7; pdb_00002bws; pdb_00002bwt; pdb_00002bwu; pdb_00002bww; pdb_00002bwy; pdb_00002iw2; pdb_00002okn; pdb_00002v3x; pdb_00002v3z; pdb_00003ctz; pdb_00003l24; pdb_00003l7g; pdb_00004qr8; pdb_00004zwo; pdb_00004zwp; pdb_00004zwu; pdb_00005jqk; pdb_00005jr6; pdb_00005m4g; pdb_00005m4j; pdb_00005m4l; pdb_00005m4q; pdb_00005mby; pdb_00005mbz; pdb_00005mc0; pdb_00005mc1; pdb_00005mc2; pdb_00005mc3; pdb_00005mc4; pdb_00005mc5; pdb_00006a9t; pdb_00006a9u; pdb_00006a9v; pdb_00006h2p; pdb_00006h2q; pdb_00006qsb; pdb_00006qsc; pdb_00006sre; pdb_00006srf; pdb_00006srg
» more