We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS00501
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PURL: https://purl.expasy.org/prosite/signature/PS00501
Direct ScanProsite submission
General information about the entry
| Entry name [info] | SPASE_I_1 |
| Accession [info] | PS00501 |
| Entry type [info] | PATTERN |
| Date [info] |
01-MAY-1991 CREATED;
01-DEC-2004 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00418 |
| Associated ProRule [info] | PRU10097 |
Name and characterization of the entry
| Description [info] | Signal peptidases I serine active site. |
| Pattern [info] |
[GS]-{PR}-S-M-{RS}-[PS]-[AT]-[LF].
|
Numerical results [info]
| Total number of hits | 185 in 185 different sequences |
| Number of true positive hits | 121 in 121 different sequences |
| Number of 'unknown' hits | 1 |
| Number of false positive hits | 63 in 63 different sequences |
| Number of false negative sequences | 21 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 65.76 % |
| Recall (true positives / (true positives + false negatives)) | 85.21 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses |
| Maximum number of repetitions [info] | 1 |
| Site [info] | active_site at position 3 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
121 sequences
IMP1_YEAST (P28627), IMP2_YEAST (P46972), LEP1_BACAM (P41026), LEP1_SYNY3 (P72660), LEP2_BACAM (P41025), LEP2_SYNY3 (P73157), LEPP_BACNA (P37943), LEPQ_BACNA (Q57350), LEPS_BACSU (P28628), LEPT_BACSU (P71013), LEPU_BACSU (P42959), LEPV_BACSU (O07560), LEP_AQUAE (O67088), LEP_BACCL (P41027), LEP_BACLI (P42668), LEP_BUCAI (P57347), LEP_BUCAP (Q8K9R0), LEP_BUCBP (Q89AM6), LEP_ECOLI (P00803), LEP_HAEIN (P44454), LEP_LEPLM (Q51876), LEP_MYCLE (O33021), LEP_MYCTO (P9WKA0), LEP_MYCTU (P9WKA1), LEP_PSEAE (Q9I5G7), LEP_PSEFL (P26844), LEP_SALTI (P0A1W3), LEP_SALTY (P0A1W2), LEP_STAAC (Q5HHB9), LEP_STAAM (P0A067), LEP_STAAN (P0A068), LEP_STAAR (Q6GIC3), LEP_STAAS (Q6GAW1), LEP_STAAU (P0A070), LEP_STAAW (P0A069), LEP_STRPN (O07344), LEP_STRR6 (P59662), PLSP1_ARATH (Q8H0W1), SC11A_BOVIN (P67810), SC11A_CANLF (P67811), SC11A_HUMAN (P67812), SC11A_MOUSE (Q9R0P6), SC11A_PONAB (Q5R9C7), SC11A_RAT (P42667), SC11B_HUMAN (P0C7V7), SC11C_CANLF (P13679), SC11C_HUMAN (Q9BY50), SC11C_MOUSE (Q9D8V7), SC11C_PONAB (Q5RC30), SC11C_RAT (Q9WTR7), SEC11_AJEC8 (F0UDD2), SEC11_AJECG (C0NKT8), SEC11_AJECH (C6HB29), SEC11_AJECN (A6QX24), SEC11_AJEDR (C5G8L5), SEC11_ARTBC (D4ALL0), SEC11_ARTGP (E4V4X0), SEC11_ARTOC (C5FQ45), SEC11_ASPCL (A1CL29), SEC11_ASPFC (B0XWT3), SEC11_ASPFU (Q4WYF4), SEC11_ASPOR (Q2UBW3), SEC11_ASPTN (Q0CQC5), SEC11_BLAGS (C5JJG5), SEC11_CANAL (Q5A869), SEC11_CANAW (C4YNJ0), SEC11_CANDC (B9WKT4), SEC11_CANTT (C5M4J6), SEC11_CHAGB (Q2H1P3), SEC11_CLAL4 (C4Y3D4), SEC11_COCP7 (C5PA33), SEC11_COCPS (E9CXH2), SEC11_COLGM (E3QXY4), SEC11_DEBHA (Q6BP15), SEC11_DICDI (Q86JD4), SEC11_EMENI (Q5B8K4), SEC11_EREGS (Q759W4), SEC11_FUSV7 (C7ZHK5), SEC11_GROCL (F0XJH4), SEC11_KLULA (Q6CMR5), SEC11_KOMPG (C4QXP7), SEC11_LACBS (B0D4L0), SEC11_LACTC (C5DDH1), SEC11_LEPMJ (E5A8D2), SEC11_LODEL (A5DS09), SEC11_METAQ (E9E796), SEC11_METRA (E9F8V9), SEC11_NEOFI (A1D6D8), SEC11_NEUCR (Q7RY44), SEC11_OGAPD (E7R7C4), SEC11_PARBA (C1GU90), SEC11_PARBD (C1FYD2), SEC11_PARBP (C0S3S0), SEC11_PENRW (B6HC89), SEC11_PICGU (A5DIZ8), SEC11_PICST (A3LXS1), SEC11_PODAN (B2B3T2), SEC11_PYRO7 (A4RGA1), SEC11_PYRTR (B2WEL2), SEC11_PYRTT (E3RR70), SEC11_SCHCM (D8Q7Q5), SEC11_SCLS1 (A7E716), SEC11_TALMQ (B6Q5G0), SEC11_TALSN (B8M5K5), SEC11_TRIVH (D4D5I1), SEC11_TUBMM (D5GNC3), SEC11_UNCRE (C4JYM4), SEC11_VERA1 (C9S8G0), SEC11_YEAS1 (B3LTI7), SEC11_YEAS2 (C7GLT4), SEC11_YEAS7 (A6ZVU2), SEC11_YEAS8 (C8ZAS4), SEC11_YEASA (E7KDY6), SEC11_YEASB (E7Q587), SEC11_YEASL (E7KQ01), SEC11_YEAST (P15367), SEC11_YEASV (E7LVX4), SEC11_YEASZ (E7QG89), SEC11_ZYGRC (C5E3W1), TPP1_ARATH (O04348), TPP2_ARATH (Q9M9Z2)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
21 sequences
IMP1L_HUMAN (Q96LU5), IMP1L_MOUSE (Q9CQU8), IMP1L_XENTR (Q28I39), IMP2L_BOVIN (Q2KI92), IMP2L_DANRE (Q6AZD4), IMP2L_HUMAN (Q96T52), IMP2L_MOUSE (Q8BPT6), IMP2L_SCHPO (Q9UST2), IMP2L_XENLA (Q5PQ63), LEPH_STAAC (Q5HHC0), LEPH_STAAM (P0A063), LEPH_STAAN (P0A064), LEPH_STAAR (Q6GIC4), LEPH_STAAS (Q6GAW2), LEPH_STAAU (P0A066), LEPH_STAAW (P0A065), LEP_HELPJ (Q9ZLQ5), LEP_HELPY (O25300), LEP_RICCN (Q92JB1), LEP_RICPR (Q9ZE32), SEC11_YARLI (Q6CAG9)» more |
| UniProtKB/Swiss-Prot 'Unknown' sequences |
1 sequence
L_CHAVB (B2C4J3) |
| UniProtKB/Swiss-Prot False positive sequences |
63 sequences
ACKL_DROME (Q9I7F7), ALDO1_ARATH (Q7G193), AQPZ_ECO57 (Q8X6K6), AQPZ_ECOL6 (P60845), AQPZ_ECOLI (P60844), AQPZ_SHIFL (O68874), ATG12_ASPCL (A1CTJ1), ATG12_ASPFU (A4D9P4), ATG12_ASPOR (Q2UMW6), ATG12_COCIM (Q1E8C2), ATG12_NEOFI (A1DMW6), ATG12_PYRO7 (Q51P78), DDL_SYNPW (A5GML7), EG1_ORYSI (A2WY00), EG1_ORYSJ (Q8S1D9), ERF1_CAEEL (O16520), FREM1_HUMAN (Q5H8C1), GNL3L_BOVIN (Q3T0J9), GNL3L_HUMAN (Q9NVN8), LVSD_DICDI (Q55AV3), NAGA_HUMAN (Q9Y303), NFAA_DICDI (Q55AR6), O51S1_HUMAN (Q8NGJ8), PEPF1_LACLC (P54124), PEPF_LACLA (Q9CEV7), PHLC_ARATH (Q8VYI2), PLSX_PARDP (A1B363), PLSX_RUEST (Q1GI68), POC1A_MOUSE (Q8JZX3), PPE19_MYCTO (P9WI24), PPE19_MYCTU (P9WI25), RIMB2_MOUSE (Q80U40), RIMB2_RAT (Q9JIR1), RS9_STRCO (Q53875), SNL4_ARATH (O04539), SNT2_YEAST (P53127), STU1_SCHPO (O42874), TBB1_AVESA (P25862), TBB1_ORYSJ (Q43594), TBB1_WHEAT (Q9ZRB2), TBB2_ELEIN (Q9ZPN9), TBB2_WHEAT (Q9ZRB1), TBB3_GOSHI (Q6VAF8), TBB3_PEA(P29502), TBB4_ELEIN (Q9ZPN7), TBB4_ORYSJ (P45960), TBB5_MAIZE (Q43697), TBB5_WHEAT (Q9ZRA8), TBB6_ARATH (P29514), TBB6_MAIZE (Q41783), TBB6_ORYSJ (Q76FS3), TBB8_MAIZE (Q41785), TBB8_ORYSJ (Q76FS2), TBB_HORVU (P93176), TDA7_CANGA (Q6FNJ6), TPIS_GRAGA (P48492), TPO5_YEAST (P36029), TRM51_VITVI (F6H2F8), UPP3_SCHPO (Q9US43), VPS10_FUSV7 (C7YGZ0), Y017_OSHVF (Q6R7K6), ZF69B_HUMAN (Q9UJL9), ZN598_DANRE (Q6PFK1)» more |
| PDB [Detailed view] |
11 PDB
pdb_00001b12; pdb_00001kn9; pdb_00001t7d; pdb_00003iiq; pdb_00003s04; pdb_00004wvh; pdb_00004wvi; pdb_00004wvj; pdb_00006b88; pdb_00007p2p; pdb_00007p2q |