PROSITE documentation PDOC00457 [for PROSITE entry PS00528]

Ribosomal protein S4e signature


A number of eukaryotic and archaebacterial ribosomal proteins can be grouped on the basis of sequence similarities. One of these families consists of:

  • Mammalian S4 [1]. Two highly similar isoforms of this protein exist : one coded by a gene on chromosome Y, and the other on chromosome X.
  • Plant cytoplasmic S4 [2]
  • Yeast S7 (YS6).
  • Archebacterial S4e.

These proteins have 233 to 264 amino acids. As a signature pattern, we selected a highly conserved stretch of 15 residues in their N-terminal section. Four positions in this region are positively charged residues.

Last update:

July 1999 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_S4E, PS00528; Ribosomal protein S4e signature  (PATTERN)


1AuthorsFisher E.M., Beer-Romero P., Brown L.G., Ridley A., McNeil J.A., Lawrence J.B., Willard H.F., Bieber F.R., Page D.C.
TitleHomologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome.
SourceCell 63:1205-1218(1990).
PubMed ID2124517

2AuthorsBraun H.P., Emmermann M., Mentzel H., Schmitz U.K.
TitlePrimary structure and expression of a gene encoding the cytosolic ribosomal protein S4 from potato.
SourceBiochim. Biophys. Acta 1218:435-438(1994).
PubMed ID8049269

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