We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS00557

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PURL: https://purl.expasy.org/prosite/signature/PS00557

Direct ScanProsite submission

General information about the entry

Entry name [info]	FMN_HYDROXY_ACID_DH_1
Accession [info]	PS00557
Entry type [info]	PATTERN
Date [info]	01-DEC-1991 CREATED; 01-DEC-1991 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00482
Associated ProRule [info]	PRU00683

Name and characterization of the entry

Description [info]	FMN-dependent alpha-hydroxy acid dehydrogenases active site.
Pattern [info]	S-N-H-G-[AG]-R-Q.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	153 in 153 different sequences
Number of true positive hits	153 in 153 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	8
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	95.03 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Site [info]	active_site at position 3
Site [info]	substrate_binding at position 6
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

153 sequences

CYB2_WICAO  (P09437), CYB2_YEAST  (P00175), FUB9_FUSO4  (A0A0D2YG00),

FUB9_GIBF5  (S0DRI9), FUB9_GIBM7  (W7NCP1), GLO1_ARATH  (Q9LRR9), 
GLO1_ORYSI  (B8AKX6), GLO1_ORYSJ  (Q10CE4), GLO2_ARATH  (Q9LRS0), 
GLO2_ORYSI  (Q01KC2), GLO2_ORYSJ  (Q7XPR4), GLO3_ORYSI  (B8AUI3), 
GLO3_ORYSJ  (Q7FAS1), GLO5_ARATH  (O49506), GLO5_ORYSI  (B8B7C5), 
GLO5_ORYSJ  (Q6YT73), GOX1_MAIZE  (A0A3L6E0R4), GOX_SPIOL   (P05414), 
HAOX1_ARATH (Q9LJH5), HAOX1_HUMAN (Q9UJM8), HAOX1_MOUSE (Q9WU19), 
HAOX1_RAT   (B0BNF9), HAOX2_ARATH (Q24JJ8), HAOX2_BOVIN (Q3ZBW2), 
HAOX2_HUMAN (Q9NYQ3), HAOX2_MOUSE (Q9NYQ2), HAOX2_RAT   (Q07523), 
HAOX_DICDI  (Q54E41), HAOX_ORYSI  (B8B8K5), HAOX_ORYSJ  (Q8H3I4), 
HMO_AMYOR   (O52792), LLDD_ACIAD  (Q6FFS1), LLDD_ACIB3  (B7H2H0), 
LLDD_ACIB5  (B7IBS4), LLDD_ACIBC  (B2I061), LLDD_ACIBS  (B0VND0), 
LLDD_ACIBT  (A3M0X0), LLDD_ACIBY  (B0V6L1), LLDD_ACTP2  (A3N3E5), 
LLDD_ACTP7  (B3GZA5), LLDD_ACTPJ  (B0BTC7), LLDD_ALCFA  (Q6WB83), 
LLDD_ALLAM  (B9K115), LLDD_AZOC5  (A8HTC9), LLDD_BARHE  (Q6G4R2), 
LLDD_BARQU  (Q6G0J2), LLDD_BART1  (A9IN89), LLDD_CAUSK  (B0T7X2), 
LLDD_CAUVC  (Q9A943), LLDD_CAUVN  (B8H3Q5), LLDD_CHRSD  (Q1R0J2), 
LLDD_CITK8  (A8ARJ1), LLDD_CROS8  (A7MNF6), LLDD_ECO24  (A7ZTF9), 
LLDD_ECO27  (B7ULG1), LLDD_ECO45  (B7MFG9), LLDD_ECO55  (B7L725), 
LLDD_ECO57  (Q8XDF7), LLDD_ECO5E  (B5YWA7), LLDD_ECO7I  (B7NPB4), 
LLDD_ECO81  (B7N251), LLDD_ECO8A  (B7M492), LLDD_ECOBW  (C4ZXJ7), 
LLDD_ECODH  (B1X8M0), LLDD_ECOHS  (A8A670), LLDD_ECOK1  (A1AHE2), 
LLDD_ECOL5  (Q0TBK1), LLDD_ECOL6  (Q8FCB1), LLDD_ECOLC  (B1IZI5), 
LLDD_ECOLI  (P33232), LLDD_ECOLU  (B7NER0), LLDD_ECOSE  (B6I3I4), 
LLDD_ECOSM  (B1LK44), LLDD_ECOUT  (Q1R4Z0), LLDD_ECTM1  (A4XYG7), 
LLDD_ENT38  (A4W540), LLDD_ESCF3  (B7LTL2), LLDD_HAEDU  (Q7VPI9), 
LLDD_HAEI8  (Q4QJK8), LLDD_HAEIE  (A5UBE3), LLDD_HAEIG  (A5UFG9), 
LLDD_HAEIN  (P46454), LLDD_KLEP3  (B5XMV0), LLDD_KLEP7  (A6TFK0), 
LLDD_MYCTO  (P9WND4), LLDD_MYCTU  (P9WND5), LLDD_PECAS  (Q6DAY3), 
LLDD_PSEA8  (B7V1I3), LLDD_PSEAB  (Q02FQ1), LLDD_PSEAE  (Q9HV37), 
LLDD_PSEE4  (Q1IF69), LLDD_PSEFS  (C3K053), LLDD_PSEP1  (A5W9B2), 
LLDD_PSEP7  (A6VCM8), LLDD_PSEPG  (B0KIT4), LLDD_PSEPK  (Q88DT3), 
LLDD_PSEPW  (B1J244), LLDD_PSEU2  (Q4ZY06), LLDD_SALA4  (B5EXA8), 
LLDD_SALAR  (A9MLC3), LLDD_SALCH  (Q57ID8), LLDD_SALDC  (B5FLH2), 
LLDD_SALEP  (B5R5C7), LLDD_SALG2  (B5RGI4), LLDD_SALHS  (B4T986), 
LLDD_SALNS  (B4SXA4), LLDD_SALPA  (Q5PLQ7), LLDD_SALPB  (A9MVJ5), 
LLDD_SALPC  (C0Q1T7), LLDD_SALPK  (B5BHX7), LLDD_SALSV  (B4TZU7), 
LLDD_SALTI  (Q8Z2E5), LLDD_SALTY  (Q8ZL61), LLDD_SERP5  (A8GIL1), 
LLDD_SHIB3  (B2U5C2), LLDD_SHIBS  (Q31V17), LLDD_SHIDS  (Q329P9), 
LLDD_SHIF8  (Q0SYD1), LLDD_SHIFL  (Q83PP7), LLDD_SHISS  (Q3YVX0), 
LLDD_STRM5  (B4SMK1), LLDD_STRMK  (B2FIJ0), LLDD_VIBCH  (Q9KKW6), 
LLDD_VIBCM  (C3LWP7), LLDD_VIBPA  (Q87G18), LLDD_XANAC  (Q8PR33), 
LLDD_XANC8  (Q4V0H2), LLDD_XANCB  (B0RLM2), LLDD_XANCP  (Q8PE75), 
LLDD_XANE5  (Q3BZH2), LLDD_XANOM  (Q2P9K0), LLDD_XANOP  (B2SUY3), 
LLDD_XANOR  (Q5H6Z4), LLDD_XANP2  (A7IMB0), LLDD_YERP3  (A7FJF0), 
LLDD_YERPA  (Q1C9P0), LLDD_YERPB  (B2JZQ1), LLDD_YERPE  (Q8ZFV8), 
LLDD_YERPG  (A9R623), LLDD_YERPN  (Q1CGZ1), LLDD_YERPP  (A4TKI4), 
LLDD_YERPS  (Q66C32), LLDD_YERPY  (B1JPU0), LMO_MYCSM   (P21795), 
LOX_AERVM   (Q44467), LOX_CHLRE   (F8WQN2), LOX_LACRM   (C2K1F0), 
LOX_LENH9   (C0XIJ3), LOX_LYSSC   (B1HZY7), LOX_NOSS1   (Q8Z0C8), 
MDLB_PSEPU  (P20932), QULF_PENCI  (P0DUR7), YKN3_SCHPO  (Q9HDX2)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

8 sequences

CYB2_TALSN  (B8MKR3), CYBL_RHOGR  (P32953), LOX_ALIDK   (F4G5A4),

LOX_LACJE   (A0A5N1I561), LOX_ROSS0   (B7RR92), LOX_STRIN   (O33655), 
MFTD_MYCTO  (P9WND6), MFTD_MYCTU  (P9WND7)

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PDB
[Detailed view]

101 PDB

pdb_00001al7; pdb_00001al8; pdb_00001fcb; pdb_00001gox; pdb_00001gyl; pdb_00001huv; pdb_00001kbi; pdb_00001kbj; pdb_00001lco; pdb_00001ldc; pdb_00001ltd; pdb_00001p4c; pdb_00001p5b; pdb_00001qcw; pdb_00001sze; pdb_00001szf; pdb_00001szg; pdb_00001tb3; pdb_00002a7n; pdb_00002a7p; pdb_00002a85; pdb_00002du2; pdb_00002e77; pdb_00002j6x; pdb_00002nli; pdb_00002nzl; pdb_00002rdt; pdb_00002rdu; pdb_00002rdw; pdb_00002w0u; pdb_00002zfa; pdb_00003giy; pdb_00003sgz; pdb_00004rje; pdb_00004yl2; pdb_00005ebu; pdb_00005qib; pdb_00005qic; pdb_00005qid; pdb_00005qie; pdb_00005qif; pdb_00005qig; pdb_00005qih; pdb_00005zzp; pdb_00005zzq; pdb_00005zzr; pdb_00005zzs; pdb_00005zzt; pdb_00005zzx; pdb_00005zzy; pdb_00005zzz; pdb_00006a00; pdb_00006a01; pdb_00006a08; pdb_00006a0b; pdb_00006a0d; pdb_00006a0g; pdb_00006a0m; pdb_00006a0o; pdb_00006a0v; pdb_00006a0y; pdb_00006a11; pdb_00006a13; pdb_00006a19; pdb_00006a1a; pdb_00006a1b; pdb_00006a1h; pdb_00006a1l; pdb_00006a1m; pdb_00006a1n; pdb_00006a1p; pdb_00006a1r; pdb_00006a1w; pdb_00006a21; pdb_00006a23; pdb_00006a24; pdb_00006a36; pdb_00006a39; pdb_00006a3d; pdb_00006a3t; pdb_00006a4g; pdb_00006a4h; pdb_00006ai7; pdb_00006bfg; pdb_00006dvh; pdb_00006dvi; pdb_00006gmb; pdb_00006gmc; pdb_00006w44; pdb_00006w45; pdb_00006w4c; pdb_00007bsr; pdb_00007f1y; pdb_00007f20; pdb_00007f21; pdb_00007f22; pdb_00007m2o; pdb_00007r4n; pdb_00007r4o; pdb_00007r4p; pdb_00008ufy
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