PRU00683
General rule information
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| Accession | PRU00683 |
| Dates | 17-JAN-2008 (Created) 19-NOV-2022 (Last updated, Version 10) |
| Data class | Domain |
| Predictors | PROSITE; PS51349; FMN_HYDROXY_ACID_DH_2 |
| Name | FMN-dependent alpha-hydroxy acid dehydrogenase domain |
| Function | These enzymes are oxidoreductases that act on alpha-hydroxy acids and which are FMN-containing flavoproteins with a TIM barrel structure. |
Propagated annotation
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Description
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case <Feature:PS51349:278=H>
| + RecName: EC 1.-.-.-; |
end case
Comments
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| Cofactor | FMN |
| Similarity | Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. |
Cross-references
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case <Feature:PS51349:278=H>
| PROSITE | PS00557; FMN_HYDROXY_ACID_DH_1; 1; |
Gene Ontology
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GO:0016491; Molecular function: oxidoreductase activity.
end case
Keywords
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case <Feature:PS51349:278=H>
end case
Features
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| From: PS51349 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | FMN hydroxy acid dehydrogenase # | |||||||||
| BINDING | 309 | 313 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | |||||||||
| BINDING | 332 | 333 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | |||||||||
| ACT_SITE | 278 | 278 | Proton acceptor | H | ||||||||
| BINDING | 27 | 27 | /ligand="a 2-oxocarboxylate" /ligand_id="ChEBI:CHEBI:35179 | Y | ||||||||
| BINDING | 109 | 109 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | S | ||||||||
| BINDING | 131 | 131 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | Q | ||||||||
| BINDING | 133 | 133 | /ligand="a 2-oxocarboxylate" /ligand_id="ChEBI:CHEBI:35179 | Y | ||||||||
| BINDING | 159 | 159 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | T | ||||||||
| BINDING | 168 | 168 | /ligand="a 2-oxocarboxylate" /ligand_id="ChEBI:CHEBI:35179 | R | ||||||||
| BINDING | 254 | 254 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210 | K | ||||||||
| BINDING | 281 | 281 | /ligand="a 2-oxocarboxylate" /ligand_id="ChEBI:CHEBI:35179 | R | ||||||||
Additional information
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| Size range | 340-390 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q6FFS1 (LLDD_ACIAD) |
| Scope | Eukaryota
Bacteria |
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UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Bacteria [128] Eukaryota [35] All [ 163 ]
- Retrieve set of proteins with 3D structure for this domain