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annotation rule: PRU00683

General rule information [?]

Accession PRU00683
Dates 17-JAN-2008 (Created)
19-DEC-2016 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51349; FMN_HYDROXY_ACID_DH_2
Name FMN-dependent alpha-hydroxy acid dehydrogenase domain
Function These enzymes are oxidoreductases that act on alpha-hydroxy acids and which are FMN-containing flavoproteins with a TIM barrel structure.

Propagated annotation [?]


Description [?]

case <Feature:PS51349:278=H>
+ RecName: EC=1.-.-.-;
end case


Comments [?]

Cofactor FMN
Similarity Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Cross-references [?]

case <Feature:PS51349:278=H>
PROSITE PS00557; FMN_HYDROXY_ACID_DH_1; 1;

Gene Ontology [?]

GO:0016491; Molecular function: oxidoreductase activity.
end case


Keywords [?]

Flavoprotein
FMN
case <Feature:PS51349:278=H>
Oxidoreductase
end case


Features [?]

From: PS51349
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       FMN hydroxy acid dehydrogenase #        
NP_BIND     309     333       FMN        
ACT_SITE     278     278       Proton acceptor     H  
BINDING     27     27       Substrate     Y  
BINDING     109     109       FMN     S  
BINDING     131     131       FMN     Q  
BINDING     133     133       Substrate     Y  
BINDING     159     159       FMN     T  
BINDING     168     168       Substrate     R  
BINDING     254     254       FMN     K  
BINDING     281     281       Substrate     R  

Additional information [?]

Size range 340-390 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q6FFS1 (LLDD_ACIAD)
Scope
Eukaryota
Bacteria

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]