ProRule PRU00683
General rule information
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| Accession | PRU00683 |
| Dates | 17-JAN-2008 (Created)
19-NOV-2022 (Last updated, Version 10) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51349; FMN_HYDROXY_ACID_DH_2 |
Name | FMN-dependent alpha-hydroxy acid dehydrogenase domain |
| Function | These enzymes are oxidoreductases that act on alpha-hydroxy acids and which are FMN-containing flavoproteins with a TIM barrel structure. |
| Scope(s) |
Eukaryota Bacteria |
| Example(s) | Q6FFS1 (LLDD_ACIAD); |
Propagated annotation
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Identifier, protein and gene names
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| case <Feature:PS51349:278=H> | |
| Protein name | + RecName: EC=1.-.-.-; |
| end case | |
Comments
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| COFACTOR | Name=FMN; Xref=ChEBI:CHEBI:58210; |
| SIMILARITY | Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. |
Keywords
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| Flavoprotein | |
| FMN | |
| case <Feature:PS51349:278=H> | |
| Oxidoreductase | |
| end case | |
Gene Ontology
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| GO:0016491; Molecular function:oxidoreductase activity | |
| end case | |
Cross-references
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| PROSITE | PS00557; FMN_HYDROXY_ACID_DH_1; 1; |
Features
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| From: PS51349 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="FMN hydroxy acid dehydrogenase #" | |||||||||
| BINDING | 309 | 313 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
|||||||||
| BINDING | 332 | 333 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
|||||||||
| ACT_SITE | 278 | 278 | /note="Proton acceptor" | H | ||||||||
| BINDING | 27 | 27 | /ligand="a 2-oxocarboxylate" /ligand_id="ChEBI:CHEBI:35179" |
Y | ||||||||
| BINDING | 109 | 109 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
S | ||||||||
| BINDING | 131 | 131 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
Q | ||||||||
| BINDING | 133 | 133 | /ligand="a 2-oxocarboxylate" /ligand_id="ChEBI:CHEBI:35179" |
Y | ||||||||
| BINDING | 159 | 159 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
T | ||||||||
| BINDING | 168 | 168 | /ligand="a 2-oxocarboxylate" /ligand_id="ChEBI:CHEBI:35179" |
R | ||||||||
| BINDING | 254 | 254 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
K | ||||||||
| BINDING | 281 | 281 | /ligand="a 2-oxocarboxylate" /ligand_id="ChEBI:CHEBI:35179" |
R | ||||||||
Additional information
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| Size range | 340-390 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [128] Eukaryota [35] All [ 163 ]
- Retrieve set of proteins with 3D structure for this domain