|PROSITE documentation PDOC00489 [for PROSITE entry PS00566]|
Fibrillarin  is a component of a nucleolar small nuclear ribonucleoprotein (SnRNP) particle thought to participate in the first step of the processing of pre-rRNA. In mammals, fibrillarin is associated with the U3, U8 and U13 small nuclear RNAs .
Fibrillarin is an extremely well conserved protein of about 320 amino acid residues. Structurally it consists of three different domains:
A protein evolutionary related to fibrillarin has been found  in archaebacteria. This protein (gene flpA) is involved in pre-rRNA processing. It lacks the Gly/Arg-rich N-terminal domain.
As a signature pattern, we selected a region that start with and encompass the RNP-2 like octapeptide sequence.Last update:
April 2006 / Pattern revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Aris J.P. Blobel G.|
|Title||cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera.|
|Source||Proc. Natl. Acad. Sci. U.S.A. 88:931-935(1991).|
|2||Authors||Bandziulis R.J. Swanson M.S. Dreyfuss G.|
|Title||RNA-binding proteins as developmental regulators.|
|Source||Genes Dev. 3:431-437(1989).|
|Source||J. Bacteriol. 176:2124-2127(1994).|