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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00583


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PURL: https://purl.expasy.org/prosite/signature/PS00583

Direct ScanProsite submission
General information about the entry

Entry name [info] PFKB_KINASES_1
Accession [info] PS00583
Entry type [info] PATTERN
Date [info] 01-DEC-1991 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00504

Name and characterization of the entry

Description [info] pfkB family of carbohydrate kinases signature 1.
Pattern [info] 
[AG]-G-x(0,1)-[GAP]-x-N-{AGLS}-[STA]-x(2)-{A}-x-{G}-{GNKA}-[GS]-x(9)-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 272 in 272 different sequences
Number of true positive hits 254 in 254 different sequences
Number of 'unknown' hits 0
Number of false positive hits 18 in 18 different sequences
Number of false negative sequences 139
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 93.38 %
Recall (true positives / (true positives + false negatives)) 64.63 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 254 sequences 

ADOK_MYCBO  (P83736), ADOK_MYCTA  (A5U4N0), ADOK_MYCTO  (P9WID4), 

ADOK_MYCTU  (P9WID5), FRLD_ECO57  (Q8X839), FRLD_ECOLI  (P45543), 
FRLD_SHIFL  (Q83JB1), HEPPK_BORBR (Q7WGU8), HLDE_ACTP2  (A3MZC0), 
HLDE_ACTPL  (Q8GLU7), HLDE_AERHH  (A0KPL4), HLDE_AERS4  (A4SIG6), 
HLDE_ALCBS  (Q0VM60), HLDE_ALIF1  (Q5E2L7), HLDE_ALIFM  (B5FB67), 
HLDE_ALISL  (B6ELZ7), HLDE_ALKEH  (Q0A4T7), HLDE_AZOVD  (C1DGT9), 
HLDE_BLOFL  (Q7VQQ6), HLDE_BLOPB  (Q493X3), HLDE_BRADU  (Q89HR3), 
HLDE_BRASB  (A5EN78), HLDE_BRASO  (A4YYB6), HLDE_CAUSK  (B0T663), 
HLDE_CAUVC  (Q9A2C5), HLDE_CHRSD  (Q1R1M6), HLDE_CITK8  (A8APT1), 
HLDE_COXBN  (A9KDJ2), HLDE_COXBR  (A9N9S2), HLDE_COXBU  (Q83B60), 
HLDE_CROS8  (A7MP93), HLDE_DICNV  (A5EWS4), HLDE_ECO24  (A7ZRT3), 
HLDE_ECO27  (B7UIW0), HLDE_ECO45  (B7MAC8), HLDE_ECO55  (B7LGY7), 
HLDE_ECO57  (Q7AAQ7), HLDE_ECO5E  (B5YR91), HLDE_ECO7I  (B7NJR5), 
HLDE_ECO81  (B7N0K1), HLDE_ECO8A  (B7LZK1), HLDE_ECOBW  (C4ZQW9), 
HLDE_ECODH  (B1XG57), HLDE_ECOHS  (A8A4K6), HLDE_ECOK1  (A1AFX4), 
HLDE_ECOL5  (Q0TD55), HLDE_ECOL6  (Q8FDH5), HLDE_ECOLC  (B1IRR4), 
HLDE_ECOLI  (P76658), HLDE_ECOLU  (B7ND40), HLDE_ECOSE  (B6I423), 
HLDE_ECOSM  (B1LF43), HLDE_ECOUT  (Q1R6S9), HLDE_ECTM1  (A4XPU9), 
HLDE_EDWI9  (C5BHH2), HLDE_ENT38  (A4WEI4), HLDE_ERWT9  (B2VGJ9), 
HLDE_ESCF3  (B7LQC9), HLDE_GEOMG  (Q39X60), HLDE_GEOSL  (Q74BF6), 
HLDE_GRABC  (Q0BUU1), HLDE_HAHCH  (Q2SN34), HLDE_HALHL  (A1WZB3), 
HLDE_HELAH  (Q17WK1), HLDE_HYDCU  (Q31IC2), HLDE_HYPNA  (Q0C190), 
HLDE_KLEP3  (B5XU40), HLDE_KLEP7  (A6TE31), HLDE_KORVE  (Q1IJZ0), 
HLDE_MAGMM  (A0L7X0), HLDE_MARMS  (A6W0Z9), HLDE_METCA  (Q607M3), 
HLDE_NITHX  (Q1QNS3), HLDE_NITOC  (Q3J7Y0), HLDE_NITWN  (Q3STQ8), 
HLDE_PARL1  (A7HUC7), HLDE_PECAS  (Q6D164), HLDE_PECCP  (C6DDL3), 
HLDE_PHOLL  (Q7N0C3), HLDE_PHOPR  (Q6LUZ5), HLDE_PROMH  (B4EW46), 
HLDE_PSE14  (Q48P39), HLDE_PSEA8  (B7V388), HLDE_PSEAB  (Q02F21), 
HLDE_PSEAE  (Q9HUG9), HLDE_PSEE4  (Q1I411), HLDE_PSEF5  (Q4KJA9), 
HLDE_PSEFS  (C3KDB8), HLDE_PSEP1  (A5W9W6), HLDE_PSEP7  (A6VDB5), 
HLDE_PSEPF  (Q3KJ28), HLDE_PSEPG  (B0KL32), HLDE_PSEPK  (Q88D93), 
HLDE_PSEPW  (B1J331), HLDE_PSESM  (Q87VF4), HLDE_PSEU2  (Q4ZZ15), 
HLDE_PSYIN  (A1SZY2), HLDE_RHOP2  (Q2IZP7), HLDE_RHOP5  (Q07RN1), 
HLDE_RHOPA  (Q6N2R5), HLDE_RHOPB  (Q219E2), HLDE_RHOPS  (Q13AN7), 
HLDE_RHOPT  (B3QJ47), HLDE_SALA4  (B5F696), HLDE_SALAR  (A9MPW3), 
HLDE_SALCH  (Q57JQ9), HLDE_SALDC  (B5FHT5), HLDE_SALEP  (B5QZ36), 
HLDE_SALG2  (B5REF8), HLDE_SALHS  (B4TI51), HLDE_SALNS  (B4T670), 
HLDE_SALPA  (Q5PC86), HLDE_SALPB  (A9N5X8), HLDE_SALPC  (C0PYX3), 
HLDE_SALPK  (B5BG11), HLDE_SALSV  (B4TVT4), HLDE_SALTI  (Q8XEW9), 
HLDE_SALTY  (Q7CPR9), HLDE_SERP5  (A8GJU3), HLDE_SHEAM  (A1S3I3), 
HLDE_SHEB2  (B8EE43), HLDE_SHEB5  (A3D837), HLDE_SHEB8  (A6WJS7), 
HLDE_SHEB9  (A9L2P0), HLDE_SHEDO  (Q12RC7), HLDE_SHEFN  (Q07Y78), 
HLDE_SHEHH  (B0TTF2), HLDE_SHELP  (A3QAN3), HLDE_SHEON  (Q8EAZ2), 
HLDE_SHEPA  (A8H086), HLDE_SHEPC  (A4Y9Z9), HLDE_SHEPW  (B8CVJ1), 
HLDE_SHESA  (A0KTG8), HLDE_SHESH  (A8FZZ3), HLDE_SHESM  (Q0HFL0), 
HLDE_SHESR  (Q0HYC0), HLDE_SHESW  (A1RGD1), HLDE_SHIB3  (B2U1F7), 
HLDE_SHIBS  (Q31WY3), HLDE_SHIDS  (Q32BR2), HLDE_SHIF8  (Q0T0L1), 
HLDE_SHIFL  (Q7UBI8), HLDE_SHISS  (Q3YXJ0), HLDE_SODGM  (Q2NWD9), 
HLDE_STUS1  (A4VR47), HLDE_TRIL1  (B3E5M9), HLDE_VIBA3  (B7VIX1), 
HLDE_VIBC1  (A7MWN3), HLDE_VIBC3  (A5F5J2), HLDE_VIBCM  (C3LQY0), 
HLDE_VIBPA  (Q87SJ9), HLDE_VIBVU  (Q8DEH7), HLDE_VIBVY  (Q7MNY3), 
HLDE_YERE8  (A1JQV6), HLDE_YERP3  (A7FE79), HLDE_YERPA  (Q1C374), 
HLDE_YERPB  (B2K2H4), HLDE_YERPE  (Q8ZI60), HLDE_YERPG  (A9R7D5), 
HLDE_YERPN  (Q1CMD4), HLDE_YERPP  (A4THT9), HLDE_YERPS  (Q665V3), 
HLDE_YERPY  (B1JM26), K1PF_BORBU  (O51575), K1PF_ECO57  (P0AEX1), 
K1PF_ECOL6  (P0AEX0), K1PF_ECOLI  (P0AEW9), K1PF_HAEIN  (P44330), 
K1PF_MYCGE  (Q49396), K1PF_MYCPN  (P75038), K1PF_RHOCA  (P23386), 
K1PF_SHIFL  (P0AEX2), K1PF_VIBCH  (Q9KM71), K1PF_XANCP  (P23354), 
LACC1_STRA3 (Q8E4R7), LACC2_STRA3 (Q8E346), LACC_ENTFA  (Q833W9), 
LACC_LACLL  (P23391), LACC_STAA1  (A7X575), LACC_STAA2  (A6U3S3), 
LACC_STAA3  (Q2FET9), LACC_STAA8  (P0A0B9), LACC_STAA9  (A5IUY2), 
LACC_STAAB  (Q2YYJ5), LACC_STAAC  (Q5HE12), LACC_STAAE  (A6QJ37), 
LACC_STAAM  (P65698), LACC_STAAN  (P65699), LACC_STAAR  (Q6GEN6), 
LACC_STAAS  (Q6G7C1), LACC_STAAT  (A8YYG0), LACC_STAAW  (P0A0B8), 
LACC_STAEQ  (Q5HM37), LACC_STAES  (Q8CRJ4), LACC_STAHJ  (Q4L872), 
LACC_STRA1  (Q3JZ20), LACC_STRA5  (Q8DXC2), LACC_STRMU  (P26421), 
LACC_STRP1  (Q99Y14), LACC_STRP2  (Q04KC3), LACC_STRP4  (B5E4T0), 
LACC_STRP7  (C1C7G0), LACC_STRPB  (Q1J9U8), LACC_STRPC  (Q1JJZ7), 
LACC_STRPD  (Q1JEY9), LACC_STRPI  (B1IBZ5), LACC_STRPJ  (B8ZQ64), 
LACC_STRPM  (Q48RC4), LACC_STRPN  (Q97QL2), LACC_STRPS  (B2IPT7), 
LACC_STRPZ  (B5XII4), LACC_STRR6  (Q8DPP1), LACC_STRSV  (A3CPH5), 
LACC_STRU0  (B9DU93), LACC_STRZJ  (C1CEF2), LACC_STRZP  (C1CKT7), 
LACC_STRZT  (C1CRA6), NK_METJA(Q57849), NK_METTH(O27587), 
PFKB_ECOLI  (P06999), PFKB_MYCTO  (P9WID2), PFKB_MYCTU  (P9WID3), 
PFKB_THETC  (D9TT10), PSUK_ECOLI  (P30235), PUKI_ARATH  (Q94AT3), 
SCKL1_ARATH (Q9M394), SCRK1_ARATH (Q9SID0), SCRK1_MAIZE (Q6XZ79), 
SCRK1_ORYSI (A2WXV8), SCRK1_ORYSJ (Q0JGZ6), SCRK2_ARATH (Q9LNE3), 
SCRK2_MAIZE (Q6XZ78), SCRK2_ORYSI (A2YQL4), SCRK2_ORYSJ (Q0J8G4), 
SCRK2_SOLHA (Q7XJ81), SCRK2_SOLLC (Q42896), SCRK3_ARATH (Q9LNE4), 
SCRK4_ARATH (Q9M1B9), SCRK5_ARATH (O82616), SCRK6_ARATH (Q9C524), 
SCRK7_ARATH (Q9FLH8), SCRK_ECOLX  (P40713), SCRK_KLEPN  (P26420), 
SCRK_SALTM  (P26984), SCRK_SOLTU  (P37829), SCRK_VIBAL  (P22824), 
Y057_BUCAP  (Q8KA54), Y060_BUCAI  (P57168), Y1459_PYRHO (O59128), 
YDJE_BACSU  (O34768), YDJH_ECOLI  (P77493), YEGV_ECOLI  (P76419), 
YEII_ECOLI  (P33020), YOW5_SCHPO  (Q9USY1)
» more

UniProtKB/Swiss-Prot
False negative sequences		 139 sequences 

ADK1_ARATH  (Q9SF85), ADK2_ARATH  (Q9LZG0), ADK_CRIGR   (P55262), 

ADK_DICDI   (Q54MB5), ADK_HUMAN   (P55263), ADK_MOUSE   (P55264), 
ADK_PHYPA   (O49923), ADK_RAT (Q64640), ADK_SCHCO   (O93919), 
ADK_SCHPO   (P78825), ADK_TOXGO   (Q9TVW2), ADK_YEAST   (P47143), 
AIRSK_SALTY (Q8ZKR2), CYDK_THEKO  (Q5JEK6), DEOK_SALTI  (P0DX97), 
DEOK_SALTY  (Q7CPF5), FRLD_BACSU  (O32153), HLDE_ACICJ  (A5FVE7), 
HLDE_ACTSZ  (A6VP06), HLDE_ALIB4  (A8EVR4), HLDE_AZOC5  (A8I5B0), 
HLDE_CAMC1  (A7ZE26), HLDE_CAMC5  (A7GZF6), HLDE_CAMFF  (A0RQR9), 
HLDE_CAMJ8  (A8FMK8), HLDE_CAMJD  (A7H2L7), HLDE_CAMJE  (Q6TG09), 
HLDE_CAMJJ  (A1W0D6), HLDE_CAMJR  (Q5HTW1), HLDE_CITBB  (B5EEZ1), 
HLDE_DESAL  (B8FB71), HLDE_GEOUR  (A5G6F4), HLDE_GLUDA  (A9HDB1), 
HLDE_GLUOX  (Q5FS52), HLDE_HAEDU  (Q7VM30), HLDE_HAEI8  (Q4QKN8), 
HLDE_HAEIE  (A5UCC3), HLDE_HAEIG  (A5UEH8), HLDE_HAEIN  (O05074), 
HLDE_HELHP  (Q7VFZ3), HLDE_HELP2  (B6JM82), HLDE_HELPG  (B5Z7L8), 
HLDE_HELPH  (Q1CT14), HLDE_HELPJ  (Q9ZKZ0), HLDE_HELPS  (B2USX2), 
HLDE_HELPY  (O25529), HLDE_HISS1  (Q0I1X5), HLDE_MANSM  (Q65T41), 
HLDE_MARN8  (A1TYR4), HLDE_METFK  (Q1H3A0), HLDE_NITSB  (A6Q4Z6), 
HLDE_PARM1  (Q2W993), HLDE_PASMU  (Q9CME6), HLDE_PELPD  (A1AV12), 
HLDE_PSET1  (Q3IHX7), HLDE_RHILO  (Q98I54), HLDE_RHORT  (Q2RY67), 
HLDE_STRCO  (Q9Z5B5), HLDE_SULDN  (Q30T22), HLDE_SYNC1  (Q3A526), 
HLDE_WOLSU  (Q7M9U1), INGK_ECO57  (P0AEW8), INGK_ECOL6  (P0AEW7), 
INGK_ECOLI  (P0AEW6), INGK_EXIAC  (O24767), IOLC1_BACCZ (Q63B75), 
IOLC2_BACCZ (Q4V1F7), IOLC_BACAA  (C3PAZ0), IOLC_BACAC  (C3LHY4), 
IOLC_BACAH  (A0REB4), IOLC_BACAN  (Q81QB7), IOLC_BACC3  (C1EVJ1), 
IOLC_BACHK  (Q6HIK4), IOLC_BACLD  (Q65D02), IOLC_BACSU  (P42414), 
IOLC_BACVZ  (A7ZAH9), IOLC_CLOB8  (A6M229), IOLC_CLOBA  (B2V4J8), 
IOLC_CLOBB  (B2TJ78), IOLC_CLOP1  (Q0TUZ4), IOLC_CLOPE  (Q8XP78), 
IOLC_CLOTE  (Q898F0), IOLC_GEOKA  (Q5KYR3), IOLC_GEOTN  (A4IPB3), 
IOLC_HALH5  (Q9KAG8), IOLC_LACCA  (A5YBJ5), IOLC_LISIN  (Q92EQ5), 
IOLC_LISMC  (C1KZA1), IOLC_LISMF  (Q723S9), IOLC_LISMH  (B8DCT6), 
IOLC_LISMO  (Q8Y9Y2), IOLC_MESH2  (Q601P9), IOLC_MESH7  (Q4A8D9), 
IOLC_MESHJ  (Q4AAB0), IOLC_PHOPR  (Q6LK43), IOLC_SHOC1  (Q5WKY9), 
K1PF_BACSU  (O31714), K1PF_HALVD  (D4GYE6), KDGK_BACSU  (P50845), 
KDGK_DICD3  (P45416), KDGK_ECOLI  (P37647), KDGK_HAEIN  (P44482), 
KDGK_PSEA6  (Q15UF1), KHK_HUMAN   (P50053), KHK_MOUSE   (P97328), 
KHK_PONAB   (Q5RD71), KHK_RAT (Q02974), LACC_CLOPE  (Q8XNK5), 
LACC_STRP3  (P0DC12), LACC_STRP6  (Q5X9Y3), LACC_STRP8  (Q8NZD9), 
LACC_STRPF  (Q1J4Q3), LACC_STRPG  (A2RGF2), LACC_STRPQ  (P0DC13), 
NK_THEAC(Q9HJT3), R1PKD_THEKO (Q5JDG9), R1PKT_HALXS (F8D4I6), 
RBSKI_FRUSL (P83534), RBSK_BACSU  (P36945), RBSK_DICDI  (Q54UQ4), 
RBSK_ECO57  (P0A9J7), RBSK_ECOLI  (P0A9J6), RBSK_HAEIN  (P44331), 
RBSK_HALH5  (Q9K6K1), RBSK_HUMAN  (Q9H477), RBSK_LACLA  (Q9CF42), 
RBSK_LEIMA  (E9AD19), RBSK_MOUSE  (Q8R1Q9), RBSK_SCHPO  (O60116), 
RBSK_YEAST  (P25332), SCKL2_ARATH (F4I0K2), SCRKL_DICDI (Q54D80), 
SCRK_RHILT  (P42720), SQUV_ECOLI  (P32143), TAGK_AGRFC  (A9CES5), 
TAGK_BACLD  (Q65EY9), TAGK_KLEOX  (Q8VS15), Y356_ARCFU  (O29891), 
YZ37_SYNY3  (Q55480)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

SCRK_SALTH  (P24261)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			18 sequences
			


			
ACOX3_ARATH (P0CZ23), AHL13_ARATH (Q940I0), DAB2_HUMAN  (P98082), 

			
DAPA1_CLOAB (Q97GI9), DAPA1_HALH5 (Q9KC32), DAPA_SYMTH  (Q67P59), 
DDROC_DEIDV (C1CYP4), GRLL_DICDI  (Q54U89), IDI2_LACLA  (Q9CIF5), 
LIS1_PICGU  (A5DJX5), REC2_ARATH  (F4JKH6), RHAB_LACPL  (Q88S49), 
RHAB_LIGS1  (Q1WRE4), SOCB_CAUVN  (A0A0H3CC30), SYYM_NEUCR  (P12063), 
THM1_THADA  (P02883), THM2_THADA  (P02884), Y1806_DICDI (Q55AN8)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			40 PDB
			


			pdb_00002awd; pdb_00002c49; pdb_00002c4e; pdb_00002f02; pdb_00002jg1; pdb_00002jgv; pdb_00002pkf; pdb_00002pkk; pdb_00002pkm; pdb_00002pkn; pdb_00002q5r; pdb_00003cqd; 
			
				pdb_00003ewm; pdb_00003gbu; pdb_00003h49; pdb_00003ih0; pdb_00003in1; pdb_00003n1c; pdb_00003umo; pdb_00003ump; pdb_00003uqd; pdb_00003uqe; pdb_00004o1g; pdb_00004pvv; 
				pdb_00004ube; pdb_00006c67; pdb_00006c9n; pdb_00006c9p; pdb_00006c9q; pdb_00006c9r; pdb_00006c9s; pdb_00006c9v; pdb_00007c1x; pdb_00007c1y; pdb_00007c1z; pdb_00007vtd; 
				pdb_00007vte; pdb_00007vtf; pdb_00007vtg; pdb_00007vva
			
			

			» more