PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00602


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS00602

Direct ScanProsite submission
General information about the entry

Entry name [info] ALDOLASE_CLASS_II_1
Accession [info] PS00602
Entry type [info] PATTERN
Date [info] 01-DEC-1991 CREATED;
01-DEC-2001 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00523

Name and characterization of the entry

Description [info] Fructose-bisphosphate aldolase class-II signature 1.
Pattern [info] 
[FYVMT]-x(1,3)-[LIVMH]-[APNT]-[LIVM]-x(1,2)-[LIVM]-H-x-D-H-[GACH].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 116 in 115 different sequences
Number of true positive hits 113 in 112 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 24
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 97.41 %
Recall (true positives / (true positives + false negatives)) 82.48 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 2
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 112 sequences 

ALF1_CERSP  (P27995), ALF1_CUPNH  (Q59100), ALF1_PARBA  (Q96UH7), 

ALF2_CERSP  (P29271), ALF2_CUPNH  (Q59101), ALF2_PARBA  (Q8J0N6), 
ALF2_SYNY3  (Q55664), ALF_ASPOR   (Q9HGY9), ALF_BACSU   (P13243), 
ALF_BORBU   (O51401), ALF_BUCAI   (P57526), ALF_BUCAP   (Q8K9B2), 
ALF_BUCBP   (Q89AB6), ALF_CAMJE   (Q0PAS0), ALF_CAMJJ   (A1VYV7), 
ALF_CANAL   (Q9URB4), ALF_CORGL   (P19537), ALF_ECO57   (P0AB72), 
ALF_ECOLI   (P0AB71), ALF_EDWI9   (O52402), ALF_GEOSE   (P94453), 
ALF_HAEIN   (P44429), ALF_HELPJ   (Q9ZMQ6), ALF_HELPY   (P56109), 
ALF_KLULA   (Q9C2U0), ALF_MYCBO   (P67476), ALF_MYCGE   (P47269), 
ALF_MYCLE   (O69600), ALF_MYCTO   (P9WQA2), ALF_MYCTU   (P9WQA3), 
ALF_NEUCR   (P53444), ALF_NOSCO   (Q9XDP3), ALF_NOSS1   (Q8YNK2), 
ALF_PSEAE   (Q9I5Y1), ALF_RHIME   (P58336), ALF_SCHPO   (P36580), 
ALF_SHIFL   (P0AB73), ALF_SINMW   (P56888), ALF_STRCO   (Q9X8R6), 
ALF_STRGB   (Q9ZEM7), ALF_STRP1   (P68905), ALF_STRP3   (P0CZ58), 
ALF_STRP6   (Q5XA12), ALF_STRP8   (P68906), ALF_STRPN   (P0A4S1), 
ALF_STRPQ   (P0CZ59), ALF_STRR6   (P0A4S2), ALF_STUST   (O87796), 
ALF_TREPA   (O83668), ALF_XANFL   (Q56815), ALF_YEAST   (P14540), 
GATY_ECO24  (A7ZNR5), GATY_ECO27  (B7UFB3), GATY_ECO45  (B7MEF1), 
GATY_ECO55  (B7L9W7), GATY_ECO57  (Q8X4R2), GATY_ECO5E  (B5YV43), 
GATY_ECO7I  (B7NPN7), GATY_ECO8A  (B7M477), GATY_ECOBW  (C4ZSI0), 
GATY_ECODH  (B1X7I7), GATY_ECOHS  (A8A1W1), GATY_ECOK1  (A1ACW2), 
GATY_ECOL5  (Q0TFZ6), GATY_ECOL6  (Q8FFY7), GATY_ECOLC  (B1IYY4), 
GATY_ECOLI  (P0C8J6), GATY_ECOLU  (B7NCC6), GATY_ECOLX  (P0C8J7), 
GATY_ECOSM  (B1LN92), GATY_ECOUT  (Q1R9X7), GATY_SALPA  (Q5PL86), 
GATY_SALPB  (A9N6Z8), GATY_SALPK  (B5BGG5), GATY_SALTI  (Q8XGZ9), 
GATY_SALTY  (Q7CPQ7), GATY_SHIB3  (B2TY92), GATY_SHIBS  (Q323C6), 
GATY_SHIF8  (Q0T342), GATY_SHIFL  (Q83QY5), GATY_SHISS  (Q3Z0B4), 
IOLJ_BACLD  (Q65D09), IOLJ_BACSU  (P42420), IOLJ_BACVZ  (A7ZAH2), 
IOLJ_HALH5  (Q9KAH3), KBAY_CITK8  (A8AQ28), KBAY_ECO24  (A7ZS33), 
KBAY_ECO27  (B7UJ37), KBAY_ECO45  (B7MB62), KBAY_ECO55  (B7LH72), 
KBAY_ECO57  (P0AB76), KBAY_ECO5E  (B5YS30), KBAY_ECO7I  (B7NKL0), 
KBAY_ECO81  (B7N0S6), KBAY_ECO8A  (B7M045), KBAY_ECOBW  (C4ZR47), 
KBAY_ECODH  (B1XGU9), KBAY_ECOHS  (A8A4V3), KBAY_ECOK1  (A1AG46), 
KBAY_ECOL5  (Q0TCW8), KBAY_ECOL6  (P0AB75), KBAY_ECOLC  (B1IRH9), 
KBAY_ECOLI  (P0AB74), KBAY_ECOLU  (B7NDC5), KBAY_ECOLX  (Q9KIP8), 
KBAY_ECOSE  (B6I1L2), KBAY_ECOSM  (B1LFP2), KBAY_ECOUT  (Q1R6K0), 
KBAY_ENT38  (A4WEV6), KBAY_ESCF3  (B7LMU4), KBAY_SALAR  (A9MPP7), 
SQIA_ALKUR  (A0A2P6MHY1)
» more

UniProtKB/Swiss-Prot
False negative sequences		 24 sequences 

ALF2_STAAC  (Q5HE75), ALF2_STAAM  (P67477), ALF2_STAAN  (P99075), 

ALF2_STAAR  (Q6GEV0), ALF2_STAAS  (Q6G7I5), ALF2_STAAW  (P67478), 
ALF2_STAEQ  (Q5HM97), ALF2_STAES  (Q8CNI3), ALF_COCIM   (P0CJ44), 
ALF_HALVD   (D4GYE0), ALF_MYCPN   (P75089), ALF_THECA   (Q703I2), 
ALF_UREPA   (Q9PPP3), GATY_KLEOX  (Q8VS16), GATY_KLEP7  (A6TEF4), 
GATY_SALCH  (Q57JK9), GATY_SALEP  (B5QZS8), GATY_SALG2  (B5REK6), 
GATY_SALHS  (B4TIX9), GATY_SALNS  (B4T6B9), GATY_SALPC  (C0PZ24), 
GATY_SALSV  (B4TWB0), GATY_SHIDS  (Q32EA9), IOLJ_SHOC1  (Q5WKY5)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

ALF2_RHOCA  (P50923), ALF_ANASL   (P83155)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			3 sequences
			


			
BANP_XENLA  (Q5FWL0), CISY_DEIRA  (Q9RWB2), CISY_HALVD  (D4GS06)


				
	

	

		PDB
[Detailed view]		
		
			40 PDB
			


			pdb_00001b57; pdb_00001dos; pdb_00001gvf; pdb_00001gyn; pdb_00001zen; pdb_00003c4u; pdb_00003c52; pdb_00003c56; pdb_00003ekl; pdb_00003ekz; pdb_00003elf; pdb_00003qm3; 
			
				pdb_00004a21; pdb_00004a22; pdb_00004def; pdb_00004del; pdb_00004lv4; pdb_00005gk3; pdb_00005gk4; pdb_00005gk5; pdb_00005gk6; pdb_00005gk7; pdb_00005gk8; pdb_00005uck; 
				pdb_00005ucn; pdb_00005ucp; pdb_00005ucs; pdb_00005ucz; pdb_00005ud0; pdb_00005ud1; pdb_00005ud2; pdb_00005ud3; pdb_00005ud4; pdb_00005vjd; pdb_00005vje; pdb_00005vjf; 
				pdb_00006lnk; pdb_00007v6f; pdb_00007v6g; pdb_00007yva
			
			

			» more