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PROSITE documentation PDOC00584 [for PROSITE entry PS00702]

Granulocyte-macrophage colony-stimulating factor signature





Description

Granulocyte-macrophage colony-stimulating factor (GM-CSF) [1,2] is a cytokine that acts in hematopoiesis by stimulating the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

GM-CSF is a glycoprotein of about 120 amino acid residues that contains four conserved cysteine residues involved in two disulfide bonds, as shown in the following schematic representation.

                                                   +---------------+
                                                   |               |
        xxxxxxxxxxxxxxxxxxxxxxxxxxCxxxxxxxxxxxxxxxxCxxxCxxxxxxxxxxxCxxx
                                  |                *****
                                  +--------------------+
'C': conserved cysteine involved in a disulfide bond.
'*': position of the pattern.

As a signature pattern, we selected the region that includes the second and third conserved cysteines.

Last update:

May 2004 / Text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

GM_CSF, PS00702; Granulocyte-macrophage colony-stimulating factor signature  (PATTERN)


References

1AuthorsMorstyn G. Burgess A.W.
TitleHemopoietic growth factors: a review.
SourceCancer Res. 48:5624-5637(1988).
PubMed ID2458827

2AuthorsWalter M.R. Cook W.J. Ealick S.E. Nagabhushan T.L. Trotta P.P. Bugg C.E.
TitleThree-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor.
SourceJ. Mol. Biol. 224:1075-1085(1992).
PubMed ID1569568



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