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PROSITE entry PS00708


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PURL: https://purl.expasy.org/prosite/signature/PS00708

Direct ScanProsite submission
General information about the entry

Entry name [info] PRO_ENDOPEP_SER
Accession [info] PS00708
Entry type [info] PATTERN
Date [info] 01-DEC-1992 CREATED;
01-DEC-1992 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00587
Associated ProRule [info] PRU10084

Name and characterization of the entry

Description [info] Prolyl endopeptidase family serine active site.
Pattern [info] 
D-x(3)-A-x(3)-[LIVMFYW]-x(14)-G-x-S-x-G-G-[LIVMFYW](2).

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 57 in 57 different sequences
Number of true positive hits 50 in 50 different sequences
Number of 'unknown' hits 1
Number of false positive hits 6 in 6 different sequences
Number of false negative sequences 71
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 89.29 %
Recall (true positives / (true positives + false negatives)) 41.32 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 50 sequences 

AARE1_ORYSJ (Q0IXP9), AARE2_ORYSJ (Q338C0), ACPH_BOVIN  (P80227), 

ACPH_HUMAN  (P13798), ACPH_MOUSE  (Q8R146), ACPH_PIG(P19205), 
ACPH_RABIT  (P25154), ACPH_RAT(P13676), DAP2_YEAST  (P18962), 
DAPB_ARTBC  (D4AQT0), DAPB_ASPTN  (Q0CXB1), DAPB_NEUCR  (Q7SHU8), 
DAPB_PARBA  (C1GT79), DAPB_PARBD  (C1FZL3), DAPB_PARBP  (C0S7H1), 
DAPB_SORMK  (D1Z9B4), DAPB_TRIVH  (D4DCG0), DBIP_DENBC  (A0A4S8L6U5), 
DPP4_ARTBC  (D4APE2), DPP4_ARTOC  (C5FJE3), DPP4_ARTOT  (A0S5V9), 
DPP4_BOVIN  (P81425), DPP4_FELCA  (Q9N2I7), DPP4_HUMAN  (P27487), 
DPP4_MOUSE  (P28843), DPP4_PIG(P22411), DPP4_RAT(P14740), 
DPP4_TRIEQ  (A7UKV8), DPP4_TRIRU  (Q5J6J3), DPP4_TRITO  (B6V868), 
DPP4_TRIVH  (D4CZ59), LEDP_LENED  (A0A1Q3EPF5), OPHP_OMPOL  (P9WEN5), 
POPA_AMABI  (E2JFG1), POPA_GALM3  (H2E7Q7), POPB_AMABI  (E2JFG2), 
POPB_GALM3  (H2E7Q8), PPCE_AERHY  (Q06903), PPCE_BOVIN  (Q9XTA2), 
PPCE_DICDI  (Q86AS5), PPCE_ELIME  (P27028), PPCE_HUMAN  (P48147), 
PPCE_MOUSE  (Q9QUR6), PPCE_PIG(P23687), PPCE_RAT(O70196), 
PPCF_ELIMR  (P27195), PTRB_ECOLI  (P24555), PTRB_MORLA  (Q59536), 
YEA8_SCHPO  (O14073), YTMA_BACSU  (O34493)
» more

UniProtKB/Swiss-Prot
False negative sequences		 71 sequences 

AARE_ARATH  (Q84LM4), APEH_AERPE  (Q9YBQ2), CGEP_ARATH  (Q8VZF3), 

CGEP_ORYSJ  (Q10MJ1), DAP4_PSEMX  (Q6F3I7), DAPB1_PSEMX (O07834), 
DAPB3_PSEMX (V5YMB3), DAPB_AJEC8  (F0U7H7), DAPB_AJECG  (C0NUQ8), 
DAPB_AJECH  (C6HRC7), DAPB_AJECN  (A6RBI0), DAPB_AJEDR  (C5GVF3), 
DAPB_ARTGP  (E4UYL6), DAPB_ARTOC  (C5FYZ3), DAPB_ASPCL  (A1CJQ1), 
DAPB_ASPFC  (B0XYK8), DAPB_ASPFN  (B8N076), DAPB_ASPFU  (Q4WX13), 
DAPB_ASPNC  (A2QEK7), DAPB_ASPNG  (Q96VT7), DAPB_ASPOR  (Q2UPW4), 
DAPB_BLAGS  (C5JC30), DAPB_BOTFB  (A6SL49), DAPB_CHAGB  (Q2HF90), 
DAPB_COCP7  (C5P334), DAPB_COCPS  (E9CUF4), DAPB_COLGM  (E3QKD2), 
DAPB_EMENI  (Q5B934), DAPB_FUSV7  (C7YYG9), DAPB_GROCL  (F0XS04), 
DAPB_METAQ  (E9ED72), DAPB_METRA  (E9ETL5), DAPB_NEOFI  (A1D7R6), 
DAPB_PENRW  (B6HFS8), DAPB_PHANO  (Q0UVK7), DAPB_PODAN  (B2A951), 
DAPB_PYRO7  (A4QYQ5), DAPB_PYRTR  (B2WC36), DAPB_PYRTT  (E3S9K3), 
DAPB_SCLS1  (A7EQZ1), DAPB_TALMQ  (B6QVW4), DAPB_TALSN  (B8MTH6), 
DAPB_TUBMM  (D5GM60), DAPB_UNCRE  (C4JHY5), DAPB_VERA1  (C9SJ15), 
DPF1_CAEEL  (Q7JKY3), DPF2_CAEEL  (Q18253), DPF6_CAEEL  (P34422), 
DPP4_ASPCL  (A1CHP1), DPP4_ASPFC  (B0Y6C5), DPP4_ASPFN  (B8N970), 
DPP4_ASPFU  (Q4WPH9), DPP4_ASPOR  (Q2UH35), DPP4_EMENI  (Q5AZ42), 
DPP4_NEOFI  (A1CX29), DPP_GIAIN   (Q95WU5), OPH_PSESP   (Q9LCQ7), 
OPH_SPHS1   (Q588Z2), PPCEL_CHICK (Q5ZKL5), PPCEL_HUMAN (Q4J6C6), 
PPCEL_MACFA (A5LFV8), PPCEL_MOUSE (Q8C167), PPCEL_PONAB (Q5RAK4), 
PPCEL_RAT   (Q5HZA6), PPCEL_XENLA (Q32N48), PTP_PORG3   (B2RJX3), 
PTP_PORGI   (Q7MUW6), STE13_YEAST (P33894), VDDP4_VESVE (P0DRB8), 
VDDP4_VESVU (B1A4F7), VDPP4_APIME (B2D0J4)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

YTAP_BACSU  (O34973)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			6 sequences
			


			
AR1AA_XENLA (Q8AVT9), AR1AB_XENLA (A0A1L8EXB5), NAR1_MYCMD  (Q4PAR1), 

			
SEPR_BOVIN  (A5D7B7), SEPR_HUMAN  (Q12884), SEPR_MOUSE  (P97321)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			154 PDB
			


			pdb_00001e5t; pdb_00001h2w; pdb_00001h2x; pdb_00001h2y; pdb_00001j2e; pdb_00001n1m; pdb_00001nu6; pdb_00001nu8; pdb_00001o6f; pdb_00001o6g; pdb_00001orv; pdb_00001orw; 
			
				pdb_00001pfq; pdb_00001qfm; pdb_00001qfs; pdb_00001r9m; pdb_00001r9n; pdb_00001rwq; pdb_00001tk3; pdb_00001tkr; pdb_00001u8e; pdb_00001vz2; pdb_00001vz3; pdb_00001w1i; 
				pdb_00001wcy; pdb_00001x70; pdb_00002aj8; pdb_00002ajb; pdb_00002ajc; pdb_00002ajd; pdb_00002ajl; pdb_00002bgn; pdb_00002bgr; pdb_00002bua; pdb_00002bub; pdb_00002buc; 
				pdb_00002fjp; pdb_00002g5p; pdb_00002g5t; pdb_00002g63; pdb_00002gbc; pdb_00002gbf; pdb_00002gbg; pdb_00002gbi; pdb_00002hha; pdb_00002i03; pdb_00002i3z; pdb_00002i78; 
				pdb_00002iit; pdb_00002iiv; pdb_00002jid; pdb_00002oae; pdb_00002oag; pdb_00002ogz; pdb_00002ole; pdb_00002onc; pdb_00002oph; pdb_00002oqi; pdb_00002oqv; pdb_00002p8s; 
				pdb_00002qjr; pdb_00002qky; pdb_00002qoe; pdb_00002qt9; pdb_00002qtb; pdb_00002rgu; pdb_00002rip; pdb_00002xdw; pdb_00003bjm; pdb_00003c43; pdb_00003c45; pdb_00003ccb; 
				pdb_00003ccc; pdb_00003d4l; pdb_00003ddu; pdb_00003eio; pdb_00003eq7; pdb_00003eq8; pdb_00003eq9; pdb_00003f8s; pdb_00003g0b; pdb_00003g0c; pdb_00003g0d; pdb_00003g0g; 
				pdb_00003h0c; pdb_00003hab; pdb_00003hac; pdb_00003kwf; pdb_00003kwj; pdb_00003nox; pdb_00003o95; pdb_00003o9v; pdb_00003oc0; pdb_00003opm; pdb_00003q0t; pdb_00003q8w; 
				pdb_00003qbj; pdb_00003sww; pdb_00003sx4; pdb_00003vjk; pdb_00003vjl; pdb_00003vjm; pdb_00003w2t; pdb_00003wqh; pdb_00004a5s; pdb_00004amy; pdb_00004amz; pdb_00004an0; 
				pdb_00004an1; pdb_00004ax4; pdb_00004bcb; pdb_00004bcc; pdb_00004bcd; pdb_00004dsa; pdb_00004dsz; pdb_00004dtc; pdb_00004ffv; pdb_00004ffw; pdb_00004g1f; pdb_00004j3j; 
				pdb_00004jh0; pdb_00004kr0; pdb_00004l72; pdb_00004lko; pdb_00004n8d; pdb_00004n8e; pdb_00004pnz; pdb_00004pv7; pdb_00004qzv; pdb_00005i7u; pdb_00005ism; pdb_00005j3j; 
				pdb_00005kby; pdb_00005lls; pdb_00005n4d; pdb_00005n4e; pdb_00005n4f; pdb_00005t4b; pdb_00005t4e; pdb_00005t4f; pdb_00005t4h; pdb_00005vta; pdb_00005y7h; pdb_00005y7j; 
				pdb_00005y7k; pdb_00005zid; pdb_00006b1e; pdb_00006b1o; pdb_00007px8; pdb_00007qun; pdb_00007xnm; pdb_00008wku; pdb_00008zdx; pdb_00008ze6
			
			

			» more