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PROSITE documentation PDOC00609 [for PROSITE entry PS00749]

F-actin capping protein alpha subunit signatures


The F-actin capping protein binds in a calcium-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike gelsolin and severin this protein does not sever actin filaments. The F-actin capping protein is a heterodimer composed of two unrelated subunits: α and β.

The α subunit is a protein of about 268 to 308 amino acid residues whose sequence is well conserved in eukaryotic species [1]. As signature patterns we selected two highly conserved regions in the C-terminal section of the α subunit.

Last update:

December 2004 / Pattern and text revised.

Technical section

PROSITE methods (with tools and information) covered by this documentation:

F_ACTIN_CAPPING_A_2, PS00749; F-actin capping protein alpha subunit signature 2  (PATTERN)

F_ACTIN_CAPPING_A_1, PS00748; F-actin capping protein alpha subunit signature 1  (PATTERN)


1AuthorsCooper J.A. Caldwell J.E. Gattermeir D.J. Torres M.A. Amatruda J.F. Casella J.F.
TitleVariant cDNAs encoding proteins similar to the alpha subunit o chicken CapZ.
SourceCell Motil. Cytoskeleton 18:204-214(1991).
PubMed ID1711931

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