Home  |  Contact
PROSITE documentation PDOC00609 [for PROSITE entry PS00749]

F-actin capping protein alpha subunit signatures





Description

The F-actin capping protein binds in a calcium-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike gelsolin and severin this protein does not sever actin filaments. The F-actin capping protein is a heterodimer composed of two unrelated subunits: α and β.

The α subunit is a protein of about 268 to 308 amino acid residues whose sequence is well conserved in eukaryotic species [1]. As signature patterns we selected two highly conserved regions in the C-terminal section of the α subunit.

Last update:

December 2004 / Pattern and text revised.

Technical section

PROSITE methods (with tools and information) covered by this documentation:

F_ACTIN_CAPPING_A_2, PS00749; F-actin capping protein alpha subunit signature 2  (PATTERN)

F_ACTIN_CAPPING_A_1, PS00748; F-actin capping protein alpha subunit signature 1  (PATTERN)


Reference

1AuthorsCooper J.A. Caldwell J.E. Gattermeir D.J. Torres M.A. Amatruda J.F. Casella J.F.
TitleVariant cDNAs encoding proteins similar to the alpha subunit o chicken CapZ.
SourceCell Motil. Cytoskeleton 18:204-214(1991).
PubMed ID1711931



PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to
Prosite License or see: prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)