It has been shown [1,2] that the following glycosyl hydrolases can be, on the
basis of sequence similarities, classified into a single family:
β glucosidases (EC 220.127.116.11) from the fungi Aspergillus wentii (A-3),
Hansenula anomala, Kluyveromyces fragilis, Saccharomycopsis fibuligera,
(BGL1 and BGL2), Schizophyllum commune and Trichoderma reesei (BGL1).
β glucosidases from the bacteria Agrobacterium tumefaciens (Cbg1),
Butyrivibrio fibrisolvens (bglA), Clostridium thermocellum (bglB),
Escherichia coli (bglX), Erwinia chrysanthemi (bgxA) and Ruminococcus
Alteromonas strain O-7 β-hexosaminidase A (EC 18.104.22.168).
Bacillus subtilis hypothetical protein yzbA.
Escherichica coli hypothetical protein ycfO and HI0959, the corresponding
Haemophilus influenzae protein.
One of the conserved regions in these enzymes is centered on a conserved
aspartic acid residue which has been shown , in Aspergillus wentii β-glucosidase A3, to be implicated in the catalytic mechanism. We have used this
region as a signature pattern.
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