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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00806


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PURL: https://purl.expasy.org/prosite/signature/PS00806

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General information about the entry

Entry name [info] ALDOLASE_CLASS_II_2
Accession [info] PS00806
Entry type [info] PATTERN
Date [info] 01-DEC-1992 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00523

Name and characterization of the entry

Description [info] Fructose-bisphosphate aldolase class-II signature 2.
Pattern [info] 
[LIVM]-E-x-E-[LIVM]-G-x(2)-[GM]-[GSTA]-x-E.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 133 in 133 different sequences
Number of true positive hits 130 in 130 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 7
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 97.74 %
Recall (true positives / (true positives + false negatives)) 94.89 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 130 sequences 

ALF1_CERSP  (P27995), ALF1_CUPNH  (Q59100), ALF1_PARBA  (Q96UH7), 

ALF2_CERSP  (P29271), ALF2_CUPNH  (Q59101), ALF2_PARBA  (Q8J0N6), 
ALF2_STAAC  (Q5HE75), ALF2_STAAM  (P67477), ALF2_STAAN  (P99075), 
ALF2_STAAR  (Q6GEV0), ALF2_STAAS  (Q6G7I5), ALF2_STAAW  (P67478), 
ALF2_STAEQ  (Q5HM97), ALF2_STAES  (Q8CNI3), ALF2_SYNY3  (Q55664), 
ALF_ASPOR   (Q9HGY9), ALF_BACSU   (P13243), ALF_BORBU   (O51401), 
ALF_BUCAI   (P57526), ALF_BUCAP   (Q8K9B2), ALF_BUCBP   (Q89AB6), 
ALF_CAMJE   (Q0PAS0), ALF_CAMJJ   (A1VYV7), ALF_CANAL   (Q9URB4), 
ALF_CORGL   (P19537), ALF_ECO57   (P0AB72), ALF_ECOLI   (P0AB71), 
ALF_EDWI9   (O52402), ALF_GEOSE   (P94453), ALF_GIAIC   (A8B2U2), 
ALF_HAEIN   (P44429), ALF_HELPJ   (Q9ZMQ6), ALF_HELPY   (P56109), 
ALF_KLULA   (Q9C2U0), ALF_MYCBO   (P67476), ALF_MYCGE   (P47269), 
ALF_MYCLE   (O69600), ALF_MYCPN   (P75089), ALF_MYCTO   (P9WQA2), 
ALF_MYCTU   (P9WQA3), ALF_NEUCR   (P53444), ALF_NOSCO   (Q9XDP3), 
ALF_NOSS1   (Q8YNK2), ALF_PSEAE   (Q9I5Y1), ALF_RHIME   (P58336), 
ALF_SCHPO   (P36580), ALF_SHIFL   (P0AB73), ALF_SINMW   (P56888), 
ALF_STRP1   (P68905), ALF_STRP3   (P0CZ58), ALF_STRP6   (Q5XA12), 
ALF_STRP8   (P68906), ALF_STRPN   (P0A4S1), ALF_STRPQ   (P0CZ59), 
ALF_STRR6   (P0A4S2), ALF_STUST   (O87796), ALF_UREPA   (Q9PPP3), 
ALF_XANFL   (Q56815), ALF_YEAST   (P14540), GATY_ECO24  (A7ZNR5), 
GATY_ECO27  (B7UFB3), GATY_ECO45  (B7MEF1), GATY_ECO55  (B7L9W7), 
GATY_ECO57  (Q8X4R2), GATY_ECO5E  (B5YV43), GATY_ECO7I  (B7NPN7), 
GATY_ECO8A  (B7M477), GATY_ECOBW  (C4ZSI0), GATY_ECODH  (B1X7I7), 
GATY_ECOHS  (A8A1W1), GATY_ECOK1  (A1ACW2), GATY_ECOL5  (Q0TFZ6), 
GATY_ECOL6  (Q8FFY7), GATY_ECOLC  (B1IYY4), GATY_ECOLI  (P0C8J6), 
GATY_ECOLU  (B7NCC6), GATY_ECOLX  (P0C8J7), GATY_ECOSM  (B1LN92), 
GATY_ECOUT  (Q1R9X7), GATY_KLEOX  (Q8VS16), GATY_KLEP7  (A6TEF4), 
GATY_SALCH  (Q57JK9), GATY_SALEP  (B5QZS8), GATY_SALG2  (B5REK6), 
GATY_SALHS  (B4TIX9), GATY_SALNS  (B4T6B9), GATY_SALPA  (Q5PL86), 
GATY_SALPB  (A9N6Z8), GATY_SALPC  (C0PZ24), GATY_SALPK  (B5BGG5), 
GATY_SALSV  (B4TWB0), GATY_SALTI  (Q8XGZ9), GATY_SALTY  (Q7CPQ7), 
GATY_SHIB3  (B2TY92), GATY_SHIBS  (Q323C6), GATY_SHIDS  (Q32EA9), 
GATY_SHIF8  (Q0T342), GATY_SHIFL  (Q83QY5), GATY_SHISS  (Q3Z0B4), 
IOLJ_BACLD  (Q65D09), IOLJ_BACSU  (P42420), IOLJ_BACVZ  (A7ZAH2), 
IOLJ_HALH5  (Q9KAH3), IOLJ_SHOC1  (Q5WKY5), KBAY_CITK8  (A8AQ28), 
KBAY_ECO24  (A7ZS33), KBAY_ECO27  (B7UJ37), KBAY_ECO45  (B7MB62), 
KBAY_ECO55  (B7LH72), KBAY_ECO57  (P0AB76), KBAY_ECO5E  (B5YS30), 
KBAY_ECO7I  (B7NKL0), KBAY_ECO81  (B7N0S6), KBAY_ECO8A  (B7M045), 
KBAY_ECOBW  (C4ZR47), KBAY_ECODH  (B1XGU9), KBAY_ECOHS  (A8A4V3), 
KBAY_ECOK1  (A1AG46), KBAY_ECOL5  (Q0TCW8), KBAY_ECOL6  (P0AB75), 
KBAY_ECOLC  (B1IRH9), KBAY_ECOLI  (P0AB74), KBAY_ECOLU  (B7NDC5), 
KBAY_ECOLX  (Q9KIP8), KBAY_ECOSE  (B6I1L2), KBAY_ECOSM  (B1LFP2), 
KBAY_ECOUT  (Q1R6K0), KBAY_ENT38  (A4WEV6), KBAY_ESCF3  (B7LMU4), 
KBAY_SALAR  (A9MPP7)
» more

UniProtKB/Swiss-Prot
False negative sequences		 7 sequences 

ALF_COCIM   (P0CJ44), ALF_HALVD   (D4GYE0), ALF_STRCO   (Q9X8R6), 

ALF_STRGB   (Q9ZEM7), ALF_THECA   (Q703I2), ALF_TREPA   (O83668), 
SQIA_ALKUR  (A0A2P6MHY1)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

ALF2_RHOCA  (P50923), ALF_ANASL   (P83155)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			3 sequences
			


			
IFT74_CHLRE (Q6RCE1), LOX21_SOLTU (O24370), MTR3_THECC  (A0A061DM17)


				
	

	

		PDB
[Detailed view]		
		
			44 PDB
			


			pdb_00001b57; pdb_00001dos; pdb_00001gvf; pdb_00001gyn; pdb_00001zen; pdb_00002isv; pdb_00002isw; pdb_00003c4u; pdb_00003c52; pdb_00003c56; pdb_00003ekl; pdb_00003ekz; 
			
				pdb_00003elf; pdb_00003gak; pdb_00003gay; pdb_00003gb6; pdb_00003ohi; pdb_00003qm3; pdb_00004a21; pdb_00004a22; pdb_00004def; pdb_00004del; pdb_00004lv4; pdb_00005gk3; 
				pdb_00005gk4; pdb_00005gk5; pdb_00005gk6; pdb_00005gk7; pdb_00005gk8; pdb_00005uck; pdb_00005ucs; pdb_00005ucz; pdb_00005ud0; pdb_00005ud1; pdb_00005ud2; pdb_00005ud3; 
				pdb_00005ud4; pdb_00005vjd; pdb_00005vje; pdb_00005vjf; pdb_00006lnk; pdb_00007v6f; pdb_00007v6g; pdb_00007yva
			
			

			» more