A number of bacterial proteins, some of which are involved in a general
secretion pathway (GSP) for the export of proteins (also called the type II
pathway) [1,2,3,4,5], have been found to be evolutionary related. These proteins
are listed below:
The 'D' protein from the GSP operon of: Aeromonas (gene exeD); Erwinia
(gene outD); Escherichia coli (gene yheF), Klebsiella pneumoniae (gene
pulD); Pseudomonas aeruginosa (gene xcpQ); Vibrio cholerae (gene epsD) and
Xanthomonas campestris (gene xpsD).
comE from Haemophilus influenzae, involved in competence (DNA uptake).
pilQ from Pseudomonas aeruginosa, which is essential for the formation of
hofQ (hopQ) from Escherichia coli.
hrpH from Pseudomonas syringae, which is involved in the secretion of a
proteinaceous elicitor of the hypersensitivity response in plants.
hrpA1 from Xanthomonas campestris pv. vesicatoria, which is also involved
in the hypersensitivity response.
mxiD from Shigella flexneri which is involved in the secretion of the Ipa
invasins which are necessary for penetration of intestinal epithelial
omc from Neisseria gonorrhoeae.
yssC from Yersinia enterocolitica virulence plasmid pYV, which seems to be
required for the export of the Yop virulence proteins.
The gpIV protein from filamentous phages such as f1, ike, or m13. GpIV is
said to be involved in phage assembly and morphogenesis.
These proteins all seem to start with a signal sequence and are thought to be
integral proteins in the outer membrane. As a signature pattern we selected a
conserved region in the C-terminal section of these proteins.
Common components in the assembly of type 4 fimbriae, DNA transfer systems, filamentous phage and protein-secretion apparatus: a general system for the formation of surface-associated protein complexes.
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