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PROSITE documentation PDOC00717 [for PROSITE entry PS00928]

Trehalase signatures





Description

Trehalase (EC 3.2.1.28) is the enzyme responsible for the degradation of the disaccharide α,α-trehalose yielding two glucose subunits [1]. It is an enzyme found in a wide variety of organisms and whose sequence has been highly conserved throughout evolution.

As signature patterns we selected two of the most highly conserved regions. The first pattern is located in the central section, the second one is in the C-terminal region.

Note:

These proteins belong to family 37 in the classification of glycosyl hydrolases [2,E1].

Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE methods (with tools and information) covered by this documentation:

TREHALASE_2, PS00928; Trehalase signature 2  (PATTERN)

TREHALASE_1, PS00927; Trehalase signature 1  (PATTERN)


References

1AuthorsKopp M. Mueller H. Holzer H.
TitleMolecular analysis of the neutral trehalase gene from Saccharomyces cerevisiae.
SourceJ. Biol. Chem. 268:4766-4774(1993).
PubMed ID8444853

2AuthorsHenrissat B. Bairoch A.
TitleNew families in the classification of glycosyl hydrolases based on amino acid sequence similarities.
SourceBiochem. J. 293:781-788(1993).
PubMed ID8352747

E1Titlehttps://www.uniprot.org/docs/glycosid



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