PROSITE documentation PDOC00727 [for PROSITE entry PS00943]
UbiA prenyltransferase family signature


The following prenyltransferases are evolutionary related [1,2]:

  • Bacterial 4-hydroxybenzoate octaprenyltransferase (gene ubiA).
  • Yeast mitochondrial para-hydroxybenzoate--polyprenyltransferase (gene COQ2).
  • Protoheme IX farnesyltransferase (heme O synthase) from yeast and mammals (gene COX10) and from bacteria (genes cyoE or ctaB).

These proteins probably contain seven transmembrane segments. The best conserved region is located in a loop between the second and third of these segments and we used it as a signature pattern.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

UBIA, PS00943; UbiA prenyltransferase family signature  (PATTERN)


1AuthorsMelzer M. Heide L.
TitleCharacterization of polyprenyldiphosphate: 4-hydroxybenzoate polyprenyltransferase from Escherichia coli.
SourceBiochim. Biophys. Acta 1212:93-102(1994).
PubMed ID8155731

2AuthorsMogi T. Saiki K. Anraku Y.
TitleBiosynthesis and functional role of haem O and haem A.
SourceMol. Microbiol. 14:391-398(1994).
PubMed ID7885224

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