|PROSITE documentation PDOC00738 [for PROSITE entry PS00955]|
Imidazoleglycerol-phosphate dehydratase (EC 220.127.116.11) is the enzyme that catalyzes the seventh step in the biosynthesis of histidine in bacteria, fungi and plants. In most organisms it is a monofunctional protein of about 22 to 29 Kd. In some bacteria such as Escherichia coli it is the C-terminal domain of a bifunctional protein that include a histidinol-phosphatase domain .
We developed two signature patterns that each include two consecutive histidine residues.Last update:
April 2006 / Pattern revised.
PROSITE methods (with tools and information) covered by this documentation:
|1||Authors||Carlomagno M.S., Chiariotti L., Alifano P., Nappo A.G., Bruni C.B.|
|Title||Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons.|
|Source||J. Mol. Biol. 203:585-606(1988).|