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PROSITE documentation PDOC00747 [for PROSITE entry PS00967]

Neuromedin U signature





Description

Neuromedin U (NmU) [1] is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C-terminally amidated.

The sequence of the C-terminal extremity of NmU is extremely well conserved [2] in mammals, birds and amphibians. We used the last seven residues as a signature pattern.

Last update:

June 1994 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

NMU, PS00967; Neuromedin U signature  (PATTERN)


References

1AuthorsDomin J. Polak J.M. Bloom S.R.
TitleThe distribution and biological effects of neuromedins B and U.
SourceAnn. N.Y. Acad. Sci. 547:391-403(1988).
PubMed ID3239891

2AuthorsDomin J. Benito-Orfila M.A. Nandha K.A. Aitken A. Bloom S.R.
TitleThe purification and sequence analysis of an avian neuromedin U.
SourceRegul. Pept. 41:1-8(1992).
PubMed ID1455013



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