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PROSITE documentation PDOC00752 [for PROSITE entry PS00976]

Myristoyl-CoA:protein N-myristoyltransferase signatures





Description

Myristoyl-CoA:protein N-myristoyltransferase (EC 2.3.1.97) (Nmt) [1] is the enzyme responsible for transferring a myristate group on the N-terminal glycine of a number of cellular eukaryotics and viral proteins.

Nmt is a monomeric protein of about 50 to 60 Kd whose sequence appears to be well conserved. We used two highly conserved regions as signature patterns. The first one is located in the central section, the second in the C-terminal part.

Last update:

April 2006 / Pattern revised.

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Technical section

PROSITE methods (with tools and information) covered by this documentation:

NMT_2, PS00976; Myristoyl-CoA:protein N-myristoyltransferase signature 2  (PATTERN)

NMT_1, PS00975; Myristoyl-CoA:protein N-myristoyltransferase signature 1  (PATTERN)


Reference

1AuthorsRudnick D.A. McWherter C.A. Gokel G.W. Gordon J.I.
TitleMyristoylCoA:protein N-myristoyltransferase.
SourceAdv. Enzymol. Relat. Areas Mol. Biol. 67:375-430(1993).
PubMed ID8322618



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