PROSITE documentation PDOC00773 [for PROSITE entry PS01011]

Folylpolyglutamate synthase signatures


Folylpolyglutamate synthase (EC (FPGS) [1] is the enzyme of folate metabolism that catalyzes ATP-dependent addition of glutamate moieties to tetrahydrofolate.

Its sequence is moderately conserved between prokaryotes (gene folC) and eukaryotes. We developed two signature patterns based on the conserved regions which are rich in glycine residues and could play a role in the catalytical activity and/or in substrate binding.

Last update:

December 2004 / Patterns and text revised.

Technical section

PROSITE methods (with tools and information) covered by this documentation:

FOLYLPOLYGLU_SYNT_1, PS01011; Folylpolyglutamate synthase signature 1  (PATTERN)

FOLYLPOLYGLU_SYNT_2, PS01012; Folylpolyglutamate synthase signature 2  (PATTERN)


1AuthorsShane B., Garrow T., Brenner A., Chen L., Choi Y.J., Hsu J.C., Stover P.
TitleFolylpoly-gamma-glutamate synthetase.
SourceAdv. Exp. Med. Biol. 338:629-634(1993).
PubMed ID8304196

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