PROSITE documentation PDOC00785 [for PROSITE entry PS01024]

Protein phosphatase 2A regulatory subunit PR55 signatures

Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase involved in many aspects of cellular function including the regulation of metabolic enzymes and proteins involved in signal transduction. PP2A is a trimeric enzyme that consists of a core composed of a catalytic subunit associated with a 65 Kd regulatory subunit (PR65), also called subunit A; this complex then associates with a third variable subunit (subunit B), which confers distinct properties to the holoenzyme [1]. One of the forms of the variable subunit is a 55 Kd protein (PR55) which is highly conserved in mammals - where three isoforms are known to exist -, Drosophila and yeast (gene CDC55). This subunit could perform a substrate recognition function or be responsible for targeting the enzyme complex to the appropriate subcellular compartment.

As signature patterns, we selected two perfectly conserved sequences of 15 residues; one located in the N-terminal region, the other in the center of the protein.