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PROSITE documentation PDOC00810 [for PROSITE entry PS01057]

SAICAR synthetase signatures





Description

Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase) catalyzes the seventh step in the de novo purine biosynthetic pathway; the ATP-dependent conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylic acid and aspartic acid to SAICAR [1]. In bacteria (gene purC), fungi (gene ADE1) and plants, SAICAR synthetase is a monofunctional protein; in higher vertebrates it is the N-terminal domain of a bifunctional enzyme that also catalyze phosphoribosylaminoimidazole carboxylase (AIRC) activity.

As signature patterns for SAICAR synthetase, we selected two conserved regions in the central section of this enzyme.

Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE methods (with tools and information) covered by this documentation:

SAICAR_SYNTHETASE_1, PS01057; SAICAR synthetase signature 1  (PATTERN)

SAICAR_SYNTHETASE_2, PS01058; SAICAR synthetase signature 2  (PATTERN)


Reference

1AuthorsZalkin H. Dixon J.E.
TitleDe novo purine nucleotide biosynthesis.
SourceProg. Nucleic Acid Res. Mol. Biol. 42:259-287(1992).
PubMed ID1574589



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