Home  |  Contact
PROSITE documentation PDOC00860 [for PROSITE entry PS01116]

Xanthine/uracil permeases family signature





Description

The following transport proteins which are involved in the uptake of xanthine or uracil are evolutionary related [1]:

  • Uric uric acid-xanthine permease (gene uapA) from Aspergillus nidulans.
  • Purine permease (gene uapC) from Aspergillus nidulans.
  • Xanthine permease from Bacillus subtilis (gene pbuX).
  • Uracil permease from Escherichia coli (gene uraA) [2] and Bacillus (gene pyrP).
  • Hypothetical protein ycdG from Escherichia coli.
  • Hypothetical protein ygfO from Escherichia coli.
  • Hypothetical protein ygfU from Escherichia coli.
  • Hypothetical protein yicE from Escherichia coli.
  • Hypothetical protein yunJ from Bacillus subtilis.
  • Hypothetical protein yunK from Bacillus subtilis.

They are proteins of from 430 to 595 residues that seem to contain 12 transmembrane domains. As a signature pattern, we selected the best conserved region which corresponds with what seems to be the tenth transmembrane domain.

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html --------------------------------------------------------------------------------.

Last update:

December 2004 / Pattern and text revised.

-------------------------------------------------------------------------------

Technical section

PROSITE method (with tools and information) covered by this documentation:

XANTH_URACIL_PERMASE, PS01116; Xanthine/uracil permeases family signature  (PATTERN)


References

1AuthorsDiallinas G. Gorfinkiel L. Arst H.N. Jr. Cecchetto G. Scazzocchio C.
TitleGenetic and molecular characterization of a gene encoding a wide specificity purine permease of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes.
SourceJ. Biol. Chem. 270:8610-8622(1995).
PubMed ID7721763

2AuthorsAndersen P.S. Frees D. Fast R. Mygind B.
TitleUracil uptake in Escherichia coli K-12: isolation of uraA mutants and cloning of the gene.
SourceJ. Bacteriol. 177:2008-2013(1995).
PubMed ID7721693



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)