We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00860Xanthine/uracil permeases family signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00860
Description
The following transport proteins which are involved in the uptake of xanthine or uracil are evolutionary related [1]:
- Uric uric acid-xanthine permease (gene uapA) from Aspergillus nidulans.
- Purine permease (gene uapC) from Aspergillus nidulans.
- Xanthine permease from Bacillus subtilis (gene pbuX).
- Uracil permease from Escherichia coli (gene uraA) [2] and Bacillus (gene pyrP).
- Hypothetical protein ycdG from Escherichia coli.
- Hypothetical protein ygfO from Escherichia coli.
- Hypothetical protein ygfU from Escherichia coli.
- Hypothetical protein yicE from Escherichia coli.
- Hypothetical protein yunJ from Bacillus subtilis.
- Hypothetical protein yunK from Bacillus subtilis.
They are proteins of from 430 to 595 residues that seem to contain 12 transmembrane domains. As a signature pattern, we selected the best conserved region which corresponds with what seems to be the tenth transmembrane domain.
Last update:December 2004 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Diallinas G. Gorfinkiel L. Arst H.N. Jr. Cecchetto G. Scazzocchio C. |
| Title | Genetic and molecular characterization of a gene encoding a wide specificity purine permease of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes. | |
| Source | J. Biol. Chem. 270:8610-8622(1995). | |
| PubMed ID | 7721763 |
| 2 | Authors | Andersen P.S. Frees D. Fast R. Mygind B. |
| Title | Uracil uptake in Escherichia coli K-12: isolation of uraA mutants and cloning of the gene. | |
| Source | J. Bacteriol. 177:2008-2013(1995). | |
| PubMed ID | 7721693 |
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