PROSITE documentation PDOC00860
Xanthine/uracil permeases family signature


The following transport proteins which are involved in the uptake of xanthine or uracil are evolutionary related [1]:

  • Uric uric acid-xanthine permease (gene uapA) from Aspergillus nidulans.
  • Purine permease (gene uapC) from Aspergillus nidulans.
  • Xanthine permease from Bacillus subtilis (gene pbuX).
  • Uracil permease from Escherichia coli (gene uraA) [2] and Bacillus (gene pyrP).
  • Hypothetical protein ycdG from Escherichia coli.
  • Hypothetical protein ygfO from Escherichia coli.
  • Hypothetical protein ygfU from Escherichia coli.
  • Hypothetical protein yicE from Escherichia coli.
  • Hypothetical protein yunJ from Bacillus subtilis.
  • Hypothetical protein yunK from Bacillus subtilis.

They are proteins of from 430 to 595 residues that seem to contain 12 transmembrane domains. As a signature pattern, we selected the best conserved region which corresponds with what seems to be the tenth transmembrane domain.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

XANTH_URACIL_PERMASE, PS01116; Xanthine/uracil permeases family signature  (PATTERN)


1AuthorsDiallinas G. Gorfinkiel L. Arst H.N. Jr. Cecchetto G. Scazzocchio C.
TitleGenetic and molecular characterization of a gene encoding a wide specificity purine permease of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes.
SourceJ. Biol. Chem. 270:8610-8622(1995).
PubMed ID7721763

2AuthorsAndersen P.S. Frees D. Fast R. Mygind B.
TitleUracil uptake in Escherichia coli K-12: isolation of uraA mutants and cloning of the gene.
SourceJ. Bacteriol. 177:2008-2013(1995).
PubMed ID7721693

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