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PROSITE documentation PDOC00860 |
The following transport proteins which are involved in the uptake of xanthine or uracil are evolutionary related [1]:
They are proteins of from 430 to 595 residues that seem to contain 12 transmembrane domains. As a signature pattern, we selected the best conserved region which corresponds with what seems to be the tenth transmembrane domain.
Last update:December 2004 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Diallinas G. Gorfinkiel L. Arst H.N. Jr. Cecchetto G. Scazzocchio C. |
Title | Genetic and molecular characterization of a gene encoding a wide specificity purine permease of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes. | |
Source | J. Biol. Chem. 270:8610-8622(1995). | |
PubMed ID | 7721763 |
2 | Authors | Andersen P.S. Frees D. Fast R. Mygind B. |
Title | Uracil uptake in Escherichia coli K-12: isolation of uraA mutants and cloning of the gene. | |
Source | J. Bacteriol. 177:2008-2013(1995). | |
PubMed ID | 7721693 |