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	PROSITE documentation PDOC00874 [for PROSITE entry PS01136]

Uncharacterized protein family UPF0034 signature

The following uncharacterized proteins have been shown [1] to share regions of similarities:

• Escherichia coli hypothetical protein yhdG and HI0979, the corresponding Haemophilus influenzae protein.
• Escherichia coli hypothetical protein yjbN and HI0634, the corresponding Haemophilus influenzae protein.
• Escherichia coli hypothetical protein yohI and HI0270, the corresponding Haemophilus influenzae protein.
• Bacillus subtilis hypothetical protein yacF.
• Rhodobacter capsulatus protein nifR3 and related proteins in Azospirillum brasilense and Rhizobium leguminosarum.
• Synechocystis strain PCC 6803 hypothetical protein slr0644.
• Synechocystis strain PCC 6803 hypothetical protein sll0926.
• Caenorhabditis elegans hypothetical protein C45G9.2.
• Yeast protein SMM1.
• Yeast hypothetical protein YLR401c.
• Yeast hypothetical protein YLR405w.
• Yeast hypothetical protein YML080w.

Although it has been proposed [2] that Rhodobacter capsulatus nifR3 is a transcriptional regulatory protein, we believe that these proteins constitute a family of enzymes whose active site could include a conserved cysteine which we have used as the central part of a signature pattern.

Last update:

April 2006 / Pattern revised.

PROSITE method (with tools and information) covered by this documentation:

UPF0034, PS01136; Uncharacterized protein family UPF0034 signature  (PATTERN)

• Consensus pattern:
  [LIVM]-[DNG]-[LIVMF]-N-x-G-C-[PS]-x(3,4)-[LIVMASQ]-x(5,6)-G-[SACY]
• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 150
  • detected by PS01136: 149 (true positives)
  • undetected by PS01136: 1 (1 false negative and 0 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS01136:
  NONE.
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01136
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01136
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS01136
• View ligand binding statistics of PS01136
• Matching PDB structures: 3B0P 3B0U 3B0V 4BF9 ... [ALL]

1	Authors	Bairoch A., Rudd K.E.
	Source	Unpublished observations (1995).

2	Authors	Foster-Hartnett D., Cullen P.J., Gabbert K.K., Kranz R.G.
	Source	Mol. Microbiol. 8:903-914(1993).

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