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PROSITE documentation PDOC00914 [for PROSITE entry PS01188]

ELO family signature





Description

The ELO family consist of eukaryotic integral membrane proteins involved in fatty acid elongation. This family consist of:

  • Mammalian proteins ELOVL1 to ELOVL4 [1]. These proteins all seem to be involved in the synthesis of very long chain fatty acids.
  • Yeast ELO1, ELO2 and ELO3 [2]. They seem to be components of membrane-bound fatty acid elongation systems.
  • Caenorhabditis elegans hypothetical protein C40H1.4.
  • Caenorhabditis elegans hypothetical protein D2024.3.

The proteins have from 271 to 435 amino acid residues. Structurally, they seem to be formed of three sections: a N-terminal region with two transmembrane domains, a central hydrophilic loop and a C-terminal region that contains from one to three transmembrane domains. As a signature pattern we selected a conserved region that contains three histidines. This region is located in the hydrophilic loop.

Last update:

January 2002 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

ELO, PS01188; ELO family signature  (PATTERN)


References

1AuthorsTvrdik P. Westerberg R. Silve S. Asadi A. Jakobsson A. Cannon B. Loison G. Jacobsson A.
TitleRole of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids.
SourceJ. Cell Biol. 149:707-718(2000).
PubMed ID10791983

2AuthorsOh C.-S. Toke D.A. Mandala S. Martin C.E.
TitleELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation.
SourceJ. Biol. Chem. 272:17376-17384(1997).
PubMed ID9211877



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