PROSITE documentation PDOC00922 [for PROSITE entry PS01199]
Ribosomal protein L1 signature


Ribosomal protein L1 is the largest protein from the large ribosomal subunit. In Escherichia coli, L1 is known to bind to the 23S rRNA. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [1,2], groups:

  • Eubacterial L1.
  • Algal and plant chloroplast L1.
  • Cyanelle L1.
  • Archaebacterial L1.
  • Vertebrate L10A.
  • Yeast SSM1.

As a signature pattern, we selected the best conserved region located in the central section of these proteins. It is located at the end of an α helix thought to be involved in RNA-binding.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_L1, PS01199; Ribosomal protein L1 signature  (PATTERN)


1AuthorsNikonov S. Nevskaya N. Eliseikina I. Fomenkova N. Nikulin A. Ossina N. Garber M. Jonsson B.-H. Briand C. Al-Karadaghi S. Svensson A. Aevarsson A. Liljas A.
TitleCrystal structure of the RNA binding ribosomal protein L1 from Thermus thermophilus.
SourceEMBO J. 15:1350-1359(1996).
PubMed ID8635468

2AuthorsOlvera J. Wool I.G.
TitleThe primary structure of rat ribosomal protein L10a.
SourceBiochem. Biophys. Res. Commun. 220:954-957(1996).
PubMed ID8607874

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