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PROSITE documentation PDOC00922 |
Ribosomal protein L1 is the largest protein from the large ribosomal subunit. In Escherichia coli, L1 is known to bind to the 23S rRNA. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [1,2], groups:
As a signature pattern, we selected the best conserved region located in the central section of these proteins. It is located at the end of an α helix thought to be involved in RNA-binding.
Last update:December 2004 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Nikonov S. Nevskaya N. Eliseikina I. Fomenkova N. Nikulin A. Ossina N. Garber M. Jonsson B.-H. Briand C. Al-Karadaghi S. Svensson A. Aevarsson A. Liljas A. |
Title | Crystal structure of the RNA binding ribosomal protein L1 from Thermus thermophilus. | |
Source | EMBO J. 15:1350-1359(1996). | |
PubMed ID | 8635468 |
2 | Authors | Olvera J. Wool I.G. |
Title | The primary structure of rat ribosomal protein L10a. | |
Source | Biochem. Biophys. Res. Commun. 220:954-957(1996). | |
PubMed ID | 8607874 |