Home  |  Contact
PROSITE documentation PDOC00938 [for PROSITE entry PS01220]

Phosphatidylethanolamine-binding protein family signature





Description

Mammalian phosphatidylethanolamine-binding protein (also knowns as basic cytosolic 21 Kd protein) is a 186 residue protein found in a variety of tissues [1]. It binds hydrophobic ligands, such as phosphatidylethanolamine, but also seems [2] to bind nucleotides such as GTP and FMN, it is suggested that it could act in membrane remodeling during growth and maturation. This protein belongs to a family that also includes:

  • Drosophila antennal protein A5, a putative odorant-binding protein.
  • Onchocerca volvulus antigen Ov-16 and the related proteins D1, D2 and D3.
  • Plasmodium falciparum putative phosphatidylethanolamine-binding protein.
  • Toxocara canis secreted antigen TES-26. This larval protein has been shown to bind phosphatidylethanolamine.
  • Yeast protein DKA1 (also known as NSP1 or TFS1). The function of this protein is not very clear.
  • Yeast hypothetical protein YLR179C.
  • Caenorhabditis elegans hypothetical protein F40A3.3.
  • Plants proteins of the 'CENTRORADIALIS' and "SELF-PRUNING' family, some of which seem to be involved in the flowering process.

As a signature pattern, we selected the best conserved region which is located in the end of the first third of the sequence of these proteins.

Expert(s) to contact by email:

Schoentgen F.

Last update:

December 2004 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

PBP, PS01220; Phosphatidylethanolamine-binding protein family signature  (PATTERN)


References

1AuthorsSeddiqi N. Bollengier F. Alliel P.M. Perin J.P. Bonnet F. Bucquoy S. Jolles P. Schoentgen F.
TitleAmino acid sequence of the Homo sapiens brain 21-23-kDa protein (neuropolypeptide h3), comparison with its counterparts from Rattus norvegicus and Bos taurus species, and expression of its mRNA in different tissues.
SourceJ. Mol. Evol. 39:655-660(1994).
PubMed ID7807553

2AuthorsSchoentgen F. Jolles P.
TitleFrom structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site.
SourceFEBS Lett. 369:22-26(1995).
PubMed ID7641877



PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to
Prosite License or see: prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)