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PROSITE documentation PDOC00940 [for PROSITE entry PS01223]

Gamma-glutamyl phosphate reductase signature





Description

γ-glutamyl phosphate reductase (EC 1.2.1.41) (GPR) is the enzyme that catalyzes the second step in the biosynthesis of proline from glutamate, the NADP-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.

In eubacteria (gene proA) and yeast [1] (gene PRO2), GPR is a monofunctional protein, while in plants and mammals, it is a bifunctional enzyme (P5CS) [2] that consists of two domains: a N-terminal glutamate 5-kinase domain (EC 2.7.2.11) (see <PDOC00701>) and a C-terminal GPR domain.

As a signature pattern, we selected a conserved region that contains two histidine residues. This region is located in the last third of GPR.

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html --------------------------------------------------------------------------------.

Last update:

April 2006 / Pattern revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

PROA, PS01223; Gamma-glutamyl phosphate reductase signature  (PATTERN)


References

1AuthorsPearson B.M. Hernando Y. Payne J. Wolf S.S. Kalogeropoulos A. Schweizer M.
TitleSequencing of a 35.71 kb DNA segment on the right arm of yeast chromosome XV reveals regions of similarity to chromosomes I and XIII.
SourceYeast 12:1021-1031(1996).
PubMed ID8896266
DOI10.1002/(SICI)1097-0061(199609)12:10B<1021::AID-YEA981>3.0.CO;2-7

2AuthorsHu C.-A.A. Delauney A.J. Verma D.P.S.
TitleA bifunctional enzyme (delta 1-pyrroline-5-carboxylate synthetase) catalyzes the first two steps in proline biosynthesis in plants.
SourceProc. Natl. Acad. Sci. U.S.A. 89:9354-9358(1992).
PubMed ID1384052



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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