PROSITE documentation PDOC00940
Gamma-glutamyl phosphate reductase signature


γ-glutamyl phosphate reductase (EC (GPR) is the enzyme that catalyzes the second step in the biosynthesis of proline from glutamate, the NADP-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.

In eubacteria (gene proA) and yeast [1] (gene PRO2), GPR is a monofunctional protein, while in plants and mammals, it is a bifunctional enzyme (P5CS) [2] that consists of two domains: a N-terminal glutamate 5-kinase domain (EC (see <PDOC00701>) and a C-terminal GPR domain.

As a signature pattern, we selected a conserved region that contains two histidine residues. This region is located in the last third of GPR.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

PROA, PS01223; Gamma-glutamyl phosphate reductase signature  (PATTERN)


1AuthorsPearson B.M. Hernando Y. Payne J. Wolf S.S. Kalogeropoulos A. Schweizer M.
TitleSequencing of a 35.71 kb DNA segment on the right arm of yeast chromosome XV reveals regions of similarity to chromosomes I and XIII.
SourceYeast 12:1021-1031(1996).
PubMed ID8896266

2AuthorsHu C.-A.A. Delauney A.J. Verma D.P.S.
TitleA bifunctional enzyme (delta 1-pyrroline-5-carboxylate synthetase) catalyzes the first two steps in proline biosynthesis in plants.
SourceProc. Natl. Acad. Sci. U.S.A. 89:9354-9358(1992).
PubMed ID1384052

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