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PROSITE documentation PDOC00948 [for PROSITE entry PS01234]

Glutamyl-tRNA(Gln) amidotransferase subunit B signature





Description

Glutamyl-tRNA(Gln) amidotransferase subunit (EC 6.3.5.-) [1] is a microbial enzyme that furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated γ-phospho-Glu-tRNA(Gln). The enzyme is composed of three subunits: A (an amidase), B and C. It also exists in eukaryotes as a protein targeted to the mitochondria.

As a signature pattern, we selected a conserved region located in the N-terminal section of these proteins.

Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

GATB, PS01234; Glutamyl-tRNA(Gln) amidotransferase subunit B signature  (PATTERN)


Reference

1AuthorsCurnow A.W. Hong K.-W. Yuan R. Kim S.I. Martins O. Winkler W. Henkin T.M. Soll D.
TitleGlu-tRNAGln amidotransferase: a novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation.
SourceProc. Natl. Acad. Sci. U.S.A. 94:11819-11826(1997).
PubMed ID9342321



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