|PROSITE documentation PDOC00953 [for PROSITE entry PS01239]|
Dynein is a multisubunit microtubule-dependent motor enzyme that acts as the force generating protein of eukaryotic cilia and flagella. The cytoplasmic isoform of dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein is composed of a number of ATP-binding large subunits, intermediate size subunits and small subunits.
- Chlamydomonas reinhardtii flagellar outer arm dynein 8 Kd and 11 Kd light chains. - Higher eukaryotes cytoplasmic dynein light chain 1. - Yeast cytoplasmic dynein light chain 1 (gene DYN2 or SLC1). - Caenorhabditis elegans hypothetical dynein light chains M18.2 and T26A5.9.
These proteins are have from 89 to 120 amino acids. As a signature pattern, we selected a highly conserved region.Last update:
December 2001 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||King S.M. Patel-King R.S.|
|Title||The M(r) = 8,000 and 11,000 outer arm dynein light chains from Chlamydomonas flagella have cytoplasmic homologues.|
|Source||J. Biol. Chem. 270:11445-11452(1995).|
|2||Authors||Dick T. Ray K. Salz H.K. Chia W.|
|Title||Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster.|
|Source||Mol. Cell. Biol. 16:1966-1977(1996).|