Arthropod express a family of neuropeptides  which so far consist of the
following types of neurohormones:
Crustacean hyperglycemic hormone (CHH). CHH is primarily involved in blood
sugar regulation, but also plays a role in the control of molting and
Molt-inhibiting hormone (MIH). MIH inhibits Y-organs where molting hormone
(ecdysteroid) is secreted. A molting cycle is initiated when MIH secretion
diminishes or stops.
Gonad-inhibiting hormone (GIH), also known as vitellogenesis-inhibiting
hormone (VIH) because of its role in inhibiting vitellogenesis in female
Mandibular organ-inhibiting hormone (MOIH). MOIH represses the synthesis of
methyl farnesoate, the precursor of insect juvenile hormone III in the
Ion transport peptide (ITP) from locust. ITP stimulates salt and water
reabsorption and inhibits acid secretion in the ileum of the locust.
Caenorhabditis elegans hypothetical protein ZC168.2.
These neurohormones are peptides of 70 to 80 residues which are processed from
larger size precursors. They contain six conserved cysteines that are involved
in disulfide bonds, as shown in the following schematic representation.
'C': conserved cysteine involved in a disulfide bond.
'*': position of the pattern.
May 2004 / Text revised.
PROSITE method (with tools and information) covered by this documentation:
De Kleijn D.P.V., Van Herp F.
Molecular biology of neurohormone precursors in the eyestalk of Crustacea.
Comp. Biochem. Physiol. 112B:573-579(1995).
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