|PROSITE documentation PDOC00970 [for PROSITE entry PS01262]|
Eukaryotic translation initiation factor 1A (eIF-1A)  (formerly known as eiF-4C) is a protein that seems to be required for maximal rate of protein biosynthesis. It enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA to 40S ribosomal subunits.
eIF-1A is a hydrophilic protein of about 15 to 17 Kd. Archaebacteria also seem to possess a eIF-1A homolog.
As a signature pattern, we selected a conserved region in the central section of these proteins.Last update:
December 2004 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Wei C.-L., Kainuma M., Hershey J.W.B.|
|Title||Characterization of yeast translation initiation factor 1A and cloning of its essential gene.|
|Source||J. Biol. Chem. 270:22788-22794(1995).|