PROSITE documentation PDOC00997 [for PROSITE entry PS01295]4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature
Description
The bacterial ispD protein [1] catalyzes the third step of the deoxyxylulose-5-phosphate pathway (DXP) of isoprenoid biosynthesis; the formation of 4-diphosphocytidyl-2C-methyl-D-erythritol from CTP and 2C-methyl-D-erythritol 4-phosphate.
These proteins can be picked up in the database by a pattern centered on a central conserved region that contains a conserved Asp and Arg residues.
Last update:December 2001 / Pattern and text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Rohdich F. Wungsintaweekul J. Fellermeier M. Sagner S. Herz S. Kis K. Eisenreich W. Bacher A. Zenk M.H. |
| Title | Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 96:11758-11763(1999). | |
| PubMed ID | 10518523 |
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