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PROSITE documentation PDOC01000 [for PROSITE entry PS01298]

Dihydrodipicolinate reductase signature





Description

Dihydrodipicolinate reductase (EC 1.3.1.26) catalyzes the second step in the biosynthesis of diaminopimelic acid and lysine, the NAD or NADP-dependent reduction of 2,3-dihydrodipicolinate into 2,3,4,5-tetrahydrodipicolinate. This enzyme is present in bacteria (gene dapB) and higher plants.

As a signature pattern we selected the best conserved region in this enzyme. It is located in the central section and is part of the substrate-binding region [1].

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html --------------------------------------------------------------------------------.

Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

DAPB, PS01298; Dihydrodipicolinate reductase signature  (PATTERN)


Reference

1AuthorsScapin G. Blanchard J.S. Sacchettini J.C.
TitleThree-dimensional structure of Escherichia coli dihydrodipicolinate reductase.
SourceBiochemistry 34:3502-3512(1995).
PubMed ID7893645



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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