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PROSITE documentation PDOC01029 [for PROSITE entry PS01326]

Diaminopimelate epimerase signature





Description

Diaminopimelate epimerase (EC 5.1.1.7) catalyzes the isomeriazation of L,L- to D,L-meso-diaminopimelate in the biosynthetic pathway leading from aspartate to lysine.

This enzyme is a protein of about 30 Kd. Two conserved cysteines seem [1] to function as the acid and base in the catalytic mechanism. As a signature pattern, we selected the region surrounding the first of these two active site cysteines.

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html --------------------------------------------------------------------------------.

Last update:

April 2006 / Pattern revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

DAP_EPIMERASE, PS01326; Diaminopimelate epimerase signature  (PATTERN)


Reference

1AuthorsCirilli M. Zheng R. Scapin G. Blanchard J.S.
TitleStructural symmetry: the three-dimensional structure of Haemophilus influenzae diaminopimelate epimerase.
SourceBiochemistry 37:16452-16458(1998).
PubMed ID9843410
DOI10.1021/bi982138o



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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