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PROSITE documentation PDOC01029 [for PROSITE entry PS01326] |
Diaminopimelate epimerase (EC 5.1.1.7) catalyzes the isomeriazation of L,L- to D,L-meso-diaminopimelate in the biosynthetic pathway leading from aspartate to lysine.
This enzyme is a protein of about 30 Kd. Two conserved cysteines seem [1] to function as the acid and base in the catalytic mechanism. As a signature pattern, we selected the region surrounding the first of these two active site cysteines.
Last update:April 2006 / Pattern revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Cirilli M. Zheng R. Scapin G. Blanchard J.S. |
Title | Structural symmetry: the three-dimensional structure of Haemophilus influenzae diaminopimelate epimerase. | |
Source | Biochemistry 37:16452-16458(1998). | |
PubMed ID | 9843410 | |
DOI | 10.1021/bi982138o |