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PROSITE documentation PDOC01030 [for PROSITE entry PS01327]

Large-conductance mechanosensitive channels mscL family signature





Description

Mechanosensitive ion channels play a critical role in transducing physical stresses at the cell membrane into an electrochemical response. Prokaryotes harbor a large-conductance mechanosensitive channel (gene mscL) [1] which is opened by membrane stretch force and may participate in the regulation of osmotic pressure changes within the cell.

MscL is a protein of about 15 kD. It forms a channel organized as a homopentamer [2], with each subunit containing two transmembrane regions.

As a signature pattern, we selected the best conserved region. It is located in the N-terminal region. It starts three residues before the beginning of the first transmembrane domain and ends in the middle of that domain.

Last update:

April 2006 / Pattern revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

MSCL, PS01327; Large-conductance mechanosensitive channels mscL family signature  (PATTERN)


References

1AuthorsMoe P.C. Blount P. Kung C.
TitleFunctional and structural conservation in the mechanosensitive channel MscL implicates elements crucial for mechanosensation.
SourceMol. Microbiol. 28:583-592(1998).
PubMed ID9632260

2AuthorsChang G. Spencer R.H. Lee A.T. Barclay M.T. Rees D.C.
TitleStructure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel.
SourceScience 282:2220-2226(1998).
PubMed ID9856938



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