PROSITE logo

PROSITE documentation PDOC01034 [for PROSITE entry PS01331]
Thymidylate kinase signature


Description

Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium. This enzyme is important in the pathway of synthesis of dTTP from dTMP. Thymidylate kinase is an ubiquitous enzyme of about 25 Kd.

As a signature pattern, we selected a region located in the central section of these proteins.

Note:

Proteins belonging to this family also contain a copy of the ATP/GTP- binding motif 'A' (P-loop) in their N-terminal extremity (see <PDOC00017>).

Last update:

December 2001 / Pattern and text revised.

-------------------------------------------------------------------------------


Technical section

PROSITE method (with tools and information) covered by this documentation:

THYMIDYLATE_KINASE, PS01331; Thymidylate kinase signature  (PATTERN)


Reference



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)