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PROSITE documentation PDOC01037 [for PROSITE entry PS01335]

Methylglyoxal synthase active site





Description

Methylglyoxal synthase (EC 4.2.3.3) (MGS) [1] catalyzes the conversion of dihydroxyacetone phosphate to methylglyoxal and phosphate. It provides bacteria with an alternative to triosephosphate isomerase for metabolizing dihydroxyacetone phosphate.

MGS is a small protein of about 13 to 17 kD. An aspartate residue is involved in the catalytic mechanism. We developed a signature pattern that includes that residue.

Last update:

April 2006 / Pattern revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

METHYLGLYOXAL_SYNTH, PS01335; Methylglyoxal synthase active site  (PATTERN)


Reference

1AuthorsSaadat D. Harrison D.H.T.
TitleThe crystal structure of methylglyoxal synthase from Escherichia coli.
SourceStructure 7:309-317(1999).
PubMed ID10368300



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