These proteins generally have two tandem copies of a domain, called LIM (for
Lin-11 Isl-1 Mec-3) in their N-terminal section. Zyxin and paxillin are
exceptions in that they contains respectively three and four LIM domains at
their C-terminal extremity. In apterous, isl-1, LH-2, lin-11, lim-1 to lim-3,
lmx-1 and ceh-14 and mec-3 there is a homeobox domain some 50 to 95 amino
acids after the LIM domains.
In the LIM domain, there are seven conserved cysteine residues and a
histidine. The arrangement followed by these conserved residues is C-x(2)-C-x(16,23)-H-x(2)-[CH]-x(2)-C-x(2)-C-x(16,21)-C-x(2,3)-[CHD]. The LIM domain
binds two zinc ions . LIM does not bind DNA, rather it seems to act as
interface for protein-protein interaction. We developed a pattern that spans
the first half of the LIM domain.
April 2005 / Profile revised.
PROSITE methods (with tools and information) covered by this documentation:
Freyd G. Kim S.K. Horvitz H.R.
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11.
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