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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS50079


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PURL: https://purl.expasy.org/prosite/signature/PS50079

Direct ScanProsite submission
General information about the entry

Entry name [info] NLS_BP
Accession [info] PS50079
Entry type [info] MATRIX
Date [info] 01-AUG-2006 CREATED;
01-APR-2007 DATA UPDATE;
01-APR-2006 INFO UPDATE.
PROSITE Doc. [info] PDOC00015
Associated ProRule [info] PRU00768

Name and characterization of the entry

Description [info] Bipartite nuclear localization signal profile.
Matrix / Profile [info] 
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=17; TOPOLOGY=LINEAR;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=17;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0; R2=1.0; TEXT='RScore';
/CUT_OFF: LEVEL=0; SCORE=4; N_SCORE=4.0; MODE=1; TEXT='*';
/CUT_OFF: LEVEL=-1; SCORE=3; N_SCORE=3.0; MODE=1; TEXT='*';
/DEFAULT: D=*; I=*; B0=*; B1=*; E0=*; E1=*; MD=0; DM=0; M0=*;

...
 
                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B0=0; B1=0;
/M: SY='B';  M=  *,  *,  *,  *,  *,  *,  *,  *,  0,  *,  *,  *,  *,  *,  0,  *,  *,  *,  *,  *;
/M: SY='B';  M=  *,  *,  *,  *,  *,  *,  *,  *,  0,  *,  *,  *,  *,  *,  0,  *,  *,  *,  *,  *;
/M:
/M:
/M:
/M:
/M:
/M:
/M:
/M:
/M: D=0;
/M: D=0;
/M: SY='B';  M=  0,  0,  0,  0,  0,  0,  0,  0,  1,  0,  0,  0,  0,  0,  1,  0,  0,  0,  0,  0;
/M: SY='B';  M=  0,  0,  0,  0,  0,  0,  0,  0,  1,  0,  0,  0,  0,  0,  1,  0,  0,  0,  0,  0;
/M: SY='B';  M=  0,  0,  0,  0,  0,  0,  0,  0,  1,  0,  0,  0,  0,  0,  1,  0,  0,  0,  0,  0;
/M: SY='B';  M=  0,  0,  0,  0,  0,  0,  0,  0,  1,  0,  0,  0,  0,  0,  1,  0,  0,  0,  0,  0;
/M: SY='B';  M=  0,  0,  0,  0,  0,  0,  0,  0,  1,  0,  0,  0,  0,  0,  1,  0,  0,  0,  0,  0;
/I:         E0=0; E1=0;
» more

Comments [info]

Matrix type [info] localization_signal
Scaling database [info] none
Skip flag [info] TRUE
Author [info] K_Hofmann, N_Hulo
Version [info] 2