|PROSITE documentation PDOC50096 [for PROSITE entry PS50096]|
The IQ motif is an extremely basic unit of about 23 amino acids, whose conserved core usually fits the consensus A-x(3)-I-Q-x(2)-F-R-x(4)-K-K. The IQ motif, which can be present in one or more copies, serves as a binding site for different EF-hand proteins (see <PDOC00018>) including the essential and regulatory myosin light chains, calmodulin (CaM), and CaM-like proteins [1,2]. Many IQ motis are protein kinase C (PKC) phosphorylation sites [3,4].
Resolution of the 3D structure of scallop myosin has shown that the IQ motif forms a basic amphipathic helix .
Some proteins known to contain an IQ motif are listed below:
The profile we developed covers the entire IQ motif.Last update:
December 2001 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Cheney R.E. Mooseker M.S.|
|Source||Curr. Opin. Cell Biol. 4:27-35(1992).|
|2||Authors||Rhoads A.R. Friedberg F.|
|Title||Sequence motifs for calmodulin recognition.|
|Source||FASEB J. 11:331-340(1997).|
|3||Authors||Baudier J. Deloulme J.C. Van Dorsselaer A. Black D. Matthes H.W.D.|
|Title||Purification and characterization of a brain-specific protein kinase C substrate, neurogranin (p17). Identification of a consensus amino acid sequence between neurogranin and neuromodulin (GAP43) that corresponds to the protein kinase C phosphorylation site and the calmodulin-binding domain.|
|Source||J. Biol. Chem. 266:229-237(1991).|
|4||Authors||Chen S.J. Klann E. Gower M.C. Powell C.M. Sessoms J.S. Sweatt J.D.|
|Title||Studies with synthetic peptide substrates derived from the neuronal protein neurogranin reveal structural determinants of potency and selectivity for protein kinase C.|
|5||Authors||Xie X. Harrison D.H. Schlichting I. Sweet R.M. Kalabokis V.N. Szent-Gyorgyi A.G. Cohen C.|
|Title||Structure of the regulatory domain of scallop myosin at 2.8 A resolution.|