The 18 residues CCHC zinc finger is mainly found in the nucleocapsid protein
of retrovirus. It is required for viral genome packaging and for early
infection process [1,2]. It is also found in eukaryotic proteins involved in
RNA binding or single-stranded DNA binding.
Some proteins known to contain a CCHC zinc finger are listed below.
Retroviral GAG protein. Nucleocapside protein.
Human CNBP protein. CNBP is involved in sterol-mediated repression. It has
also been shown to bind the 5' untranslated region of ribosomal proteins
mRNA (a region known to be important in translational regulation).
Yeast BYR3; the CNBP homolog.
Caenorhabditis elegans protein glh-1; a probable ATP-binding RNA helicase.
Leishmania major hexamer-binding protein (HEXP). It binds the 5'
untranslated region of the GP63 gene.
Tobbacco transposon TNT1 PolX protein. Retrovirus-related pol polyprotein.
The profile we developed covers the whole domain.
January 2002 / First entry.
PROSITE method (with tools and information) covered by this documentation:
Katz R.A. Jentoft J.E.
What is the role of the cys-his motif in retroviral nucleocapsid (NC) proteins?
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