|PROSITE documentation PDOC50186 [for PROSITE entry PS50186]|
The DEP domain is a globular domain of about 80 residues that is found in more than 50 proteins involved in G protein signaling pathways. It has been named after the three proteins (Dishevelled, Egl-10, and Pleckstrin) in which it was initially identified . It has been proposed that the DEP domain could play a selective role in targeting DEP domain-containing proteins to specific subcellular membranous sites, perhaps even to specific G protein-coupled signaling pathways [2,3].
Nuclear magnetic resonance spectroscopy has revealed that the DEP domain comprises a three-helix bundle, a β-hairpin 'arm' composed of two β-strands and two short β-strands in the C-terminal region .
Representative example of proteins containing DEP domains are listed below:
The profile we developed covers the entire DEP domain.Last update:
December 2001 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Ponting C.P. Bork P.|
|Title||Pleckstrin's repeat performance: a novel domain in G-protein signaling?|
|Source||Trends Biochem. Sci. 21:245-246(1996).|
|Title||Regulators of G protein signaling: a bestiary of modular protein binding domains.|
|Source||J. Neurochem. 75:1335-1351(2000).|
|3||Authors||Wong H.C. Mao J. Nguyen J.T. Srinivas S. Zhang W. Liu B. Li L. Wu D. Zheng J.|
|Title||Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway.|
|Source||Nat. Struct. Biol. 7:1178-1184(2000).|