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PROSITE documentation PDOC50244 [for PROSITE entry PS50244]

Steroid 5-alpha reductase C-terminal domain profile





Description

Steroid 5-α reductases (EC 1.3.99.5) are responsible for the NADPH-dependent reduction of testosterone into dihydrotestosterone, a key reaction in androgen action [1]. This enzyme is also found in plants where it is involved in brassinosteroids biosynthesis [2]. A domain of around 80 amino acids is found in the C-terminal part of the protein and contains the binding site for NADPH [3].

Last update:

April 2002 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

S5A_REDUCTASE, PS50244; Steroid 5-alpha reductase C-terminal domain profile  (MATRIX)


References

1AuthorsRussell D.W. Wilson J.D.
TitleSteroid 5 alpha-reductase: two genes/two enzymes.
SourceAnnu. Rev. Biochem. 63:25-61(1994).
PubMed ID7979239
DOI10.1146/annurev.bi.63.070194.000325;

2AuthorsLi J. Biswas M.G. Chao A. Russell D.W. Chory J.
TitleConservation of function between mammalian and plant steroid 5alpha-reductases.
SourceProc. Natl. Acad. Sci. U.S.A. 94:3554-3559(1997).
PubMed ID9108014

3AuthorsBhattacharyya A.K. Chavan A.J. Haley B.E. Taylor M.F. Collins D.C.
TitleIdentification of the NADP(H) binding site of rat liver microsomal 5 alpha-reductase (isozyme-1): purification of a photolabeled peptide corresponding to the adenine binding domain.
SourceBiochemistry 34:3663-3669(1995).
PubMed ID7893662



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