Steroid 5-α reductases (EC 22.214.171.124) are responsible for the NADPH-dependent reduction of testosterone into dihydrotestosterone, a key reaction
in androgen action . This enzyme is also found in plants where it is
involved in brassinosteroids biosynthesis . A domain of around 80 amino
acids is found in the C-terminal part of the protein and contains the binding
site for NADPH .
April 2002 / First entry.
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