PROSITE documentation PDOC50244 [for PROSITE entry PS50244]

Steroid 5-alpha reductase C-terminal domain profile





Description

Steroid 5-α reductases (EC 1.3.99.5) are responsible for the NADPH-dependent reduction of testosterone into dihydrotestosterone, a key reaction in androgen action [1]. This enzyme is also found in plants where it is involved in brassinosteroids biosynthesis [2]. A domain of around 80 amino acids is found in the C-terminal part of the protein and contains the binding site for NADPH [3].

Last update:

April 2002 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

S5A_REDUCTASE, PS50244; Steroid 5-alpha reductase C-terminal domain profile  (MATRIX)


References

1AuthorsRussell D.W., Wilson J.D.
TitleSteroid 5 alpha-reductase: two genes/two enzymes.
SourceAnnu. Rev. Biochem. 63:25-61(1994).
PubMed ID7979239
DOI10.1146/annurev.bi.63.070194.000325;

2AuthorsLi J., Biswas M.G., Chao A., Russell D.W., Chory J.
TitleConservation of function between mammalian and plant steroid 5alpha-reductases.
SourceProc. Natl. Acad. Sci. U.S.A. 94:3554-3559(1997).
PubMed ID9108014

3AuthorsBhattacharyya A.K., Chavan A.J., Haley B.E., Taylor M.F., Collins D.C.
TitleIdentification of the NADP(H) binding site of rat liver microsomal 5 alpha-reductase (isozyme-1): purification of a photolabeled peptide corresponding to the adenine binding domain.
SourceBiochemistry 34:3663-3669(1995).
PubMed ID7893662



PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to
Prosite License or see: prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)