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PROSITE documentation PDOC00862 [for PROSITE entry PS50296]

Translation initiation factor SUI1 profile





Description

In budding yeast (Saccharomyces cerevisiae), SUI1 is a translation initiation factor that functions in concert with eIF-2 and the initiator tRNA-Met in directing the ribosome to the proper start site of translation [1]. SUI1 is a protein of 108 residues. Close homologs of SUI1 have been found [2] in mammals, insects and plants.

SUI1 is also evolutionary related to:

  • Hypothetical proteins from bacteria such as Escherichia coli (yciH) or Haemophilus influenzae (HI1225).
  • Hypothetical proteins from archaea such as Methanococcus jannaschii (MJ0463).

Two eukaryotic proteins also seem to contain a C-terminal SUI1-like domain. These are:

  • Density-regulated protein (gene: DENR). This protein is found in mammals, insects, nematodes, plants and fungi.
  • Ligatin (gene: LGTN). This protein is found in mammals and insects.

The profile we developed covers the entire C-terminal SUI1-like domain.

Last update:

August 2003 / Pattern removed.

Technical section

PROSITE method (with tools and information) covered by this documentation:

SUI1, PS50296; Translation initiation factor SUI1 family profile  (MATRIX)


References

1AuthorsYoon H.J. Donahue T.F.
TitleThe suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon.
SourceMol. Cell. Biol. 12:248-260(1992).
PubMed ID1729602

2AuthorsFields C.A. Adams M.D.
TitleExpressed sequence tags identify a human isolog of the suil translation initiation factor.
SourceBiochem. Biophys. Res. Commun. 198:288-291(1994).
PubMed ID7904817



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