Home ScanProsite ProRule Documents Downloads Links Funding
	PROSITE documentation PDOC00862 [for PROSITE entry PS50296]

Translation initiation factor SUI1 profile

In budding yeast (Saccharomyces cerevisiae), SUI1 is a translation initiation factor that functions in concert with eIF-2 and the initiator tRNA-Met in directing the ribosome to the proper start site of translation [1]. SUI1 is a protein of 108 residues. Close homologs of SUI1 have been found [2] in mammals, insects and plants.

SUI1 is also evolutionary related to:

• Hypothetical proteins from bacteria such as Escherichia coli (yciH) or Haemophilus influenzae (HI1225).
• Hypothetical proteins from archaea such as Methanococcus jannaschii (MJ0463).

Two eukaryotic proteins also seem to contain a C-terminal SUI1-like domain. These are:

• Density-regulated protein (gene: DENR). This protein is found in mammals, insects, nematodes, plants and fungi.
• Ligatin (gene: LGTN). This protein is found in mammals and insects.

The profile we developed covers the entire C-terminal SUI1-like domain.

Last update:

August 2003 / Pattern removed.

PROSITE method (with tools and information) covered by this documentation:

SUI1, PS50296; Translation initiation factor SUI1 family profile  (MATRIX)

• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 113
  • detected by PS50296: 113 (true positives)
  • undetected by PS50296: 0 (false negative or 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS50296:
  1 unknown.
• Domain architecture view of Swiss-Prot proteins matching PS50296
  
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS50296
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS50296
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS50296
• View ligand binding statistics of PS50296
• Matching PDB structures: 1D1R 2IF1 2OGH 2RVH ... [ALL]

1	Authors	Yoon H.J., Donahue T.F.
	Title	The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon.
	Source	Mol. Cell. Biol. 12:248-260(1992).
	PubMed ID	1729602

2	Authors	Fields C.A., Adams M.D.
	Title	Expressed sequence tags identify a human isolog of the suil translation initiation factor.
	Source	Biochem. Biophys. Res. Commun. 198:288-291(1994).
	PubMed ID	7904817

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to

Prosite License or see: prosite_license.html.


View entry in original PROSITE document format
View entry in raw text format (no links)